{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:51:56Z","timestamp":1753883516906,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":64,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Despite multiple intracranial and extracranial relapses associated with a widely metastatic meningeal solitary fibrous tumor (formerly classified as hemangiopericytoma), a 66-year-old type 2 diabetic man was first diagnosed with paraneoplastic hypoglycemia 23 years after the original diagnosis and 12 years after the onset of extracranial metastatic disease. An enlarging mass entirely replacing the left kidney measuring 11.6 \u00d7 10 \u00d7 28\u2005cm, which had not been locally treated before, was considered to be the putative source of IGF-2 excess. The insulin-like effects of IGF-2 not only ameliorated his long-standing type 2 diabetes mellitus, but also caused spontaneous fasting hypoglycemia. The physiopathology, clinical manifestations, diagnostic approach, and treatment of non-islet cell tumor hypoglycemia are briefly discussed here. Palliative tumor debulking improved the hypoglycemia by day 11 after radiation therapy and glucose monitoring with continuous glucose monitoring system (Dexcom G6) facilitated the patient's management and gave him peace of mind.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad001","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:33:57Z","timestamp":1675298037000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypoglycemia From Metastatic Meningeal Solitary Fibrous Tumor Occurring Over Two Decades After Initial Diagnosis"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-5946","authenticated-orcid":false,"given":"John J","family":"Orrego","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Colorado Permanente Medical Group, P.C. , Denver, CO 80205 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0112-0592","authenticated-orcid":false,"given":"Joseph A","family":"Chorny","sequence":"additional","affiliation":[{"name":"Department of Pathology, Colorado Permanente Medical Group, P.C. , Denver, CO 80239 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"issue":"6","key":"2023100215472480200_luad001-B1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1210\/er.2012-1033","article-title":"Tumors, IGF-2 and hypoglycemia: insights from the clinic, the laboratory and the historical archive","volume":"34","author":"Dynkevich","year":"2013","journal-title":"Endocr Rev"},{"issue":"6","key":"2023100215472480200_luad001-B2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central 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stratification model","volume":"30","author":"Demicco","year":"2017","journal-title":"Mod Pathol"},{"issue":"2","key":"2023100215472480200_luad001-B6","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng.2509","article-title":"Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing","volume":"45","author":"Robinson","year":"2013","journal-title":"Nat Genet"},{"key":"2023100215472480200_luad001-B7","first-page":"1","article-title":"Non-islet cell tumor-induced hypoglycemia in the setting of metastatic intracranial hemangiopericytoma: case report and review of the literature","volume":"10","author":"Nussbaum","year":"2019","journal-title":"Br J Neurosurg"},{"issue":"4","key":"2023100215472480200_luad001-B8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ghir.2006.05.003","article-title":"Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia","volume":"16","author":"Fukuda","year":"2006","journal-title":"Growth Hormone IGF Res"},{"issue":"1","key":"2023100215472480200_luad001-B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-020-00624-2","article-title":"Extraordinarily long-inactive solitary fibrous tumor transformed to produce big insulin-like growth factor-2, leading to hypoglycemia and rapid liposarcoma growth: a case report","volume":"20","author":"Kaneko","year":"2020","journal-title":"BMC Endocr Disord"},{"issue":"3","key":"2023100215472480200_luad001-B10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1210\/jc.2013-3382","article-title":"Management of non-islet-cell tumor hypoglycemia: a clinical review","volume":"99","author":"Bodnar","year":"2014","journal-title":"J Clin Endo Metab"}],"container-title":["JCEM Case 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