{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:06:26Z","timestamp":1757311586786,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 27-year-old woman presented with an epigastric mass, accompanied by emesis and weight loss. An abdominal computed tomography (CT) scan showed a pancreatic head-body mass and liver metastasis. Biopsy revealed well-differentiated pancreatic neuroendocrine tumor, grade 3. Chromogranin and synaptophysin stains were positive, with a Ki-67 index of 33.6%. Increased frequency of episodic emesis with incomprehensible speech and right-sided weakness prompted admission. A cranial magnetic resonance imaging (MRI) scan showed a subacute cerebrovascular infarct. Serum glucagon was markedly elevated. On the third hospital day, neurologic symptoms progressed, with repeat cranial MRI demonstrating acute lacunar infarcts. Two-dimensional echocardiography was consistent with dilated cardiomyopathy. Because of her fragile condition, she was not a candidate for surgery and chemotherapy. She was treated with long-acting octreotide every 4 weeks for a total of 10 doses. Posttreatment, a 2-dimensional echocardiogram and an abdominal CT scan showed no significant change. We report a rare case of glucagonoma with associated prominently dilated cardiomyopathy and ischemic stroke.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad008","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T13:07:47Z","timestamp":1676898467000},"source":"Crossref","is-referenced-by-count":1,"title":["Glucagonoma-induced Dilated Cardiomyopathy in a Young Woman"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-9900","authenticated-orcid":false,"given":"Jennifer Lourdes","family":"Ng","sequence":"first","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine St. Luke's Medical Center , Quezon City, Philippines 1112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee Matthew","family":"Ponce","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine St. Luke's Medical Center , Quezon City, Philippines 1112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-1108","authenticated-orcid":false,"suffix":"Jr","given":"Gabriel","family":"Jasul","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine St. Luke's Medical Center , Quezon City, Philippines 1112"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"issue":"3","key":"2024010813075075000_luad008-B1","first-page":"2749","article-title":"Glucagonoma and the glucagonoma syndrome","volume":"15","author":"Song","year":"2018","journal-title":"Oncol Lett"},{"key":"2024010813075075000_luad008-B2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/1752-1947-5-402","article-title":"Glucagonoma syndrome: a case report","volume":"5","author":"Castro","year":"2011","journal-title":"J Med Case 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insufficiency]","volume":"34","author":"de Mestier","year":"2010","journal-title":"Gastroenterol Clin Biol"},{"issue":"5","key":"2024010813075075000_luad008-B9","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1210\/jc.2018-00050","article-title":"Hemodynamic effects of glucagon: a literature review","volume":"103","author":"Petersen","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"2024010813075075000_luad008-B10","first-page":"7659341","article-title":"A glucagonoma presenting as cerebral vein thrombosis and diabetes","volume-title":"Case Rep Endocrinol","author":"Delli Colli","year":"2022"}],"container-title":["JCEM Case 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