{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:32:26Z","timestamp":1759336346829,"version":"3.41.2"},"reference-count":9,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We report a case of a 58-year-old woman with a history of hypertension diagnosed at aged 35 years, on 5 antihypertensive agents and a history of intermittent spontaneous hypokalemia, was found to have a 6-cm left adrenal mass on computed tomography scan of the abdomen. The unenhanced computed tomography attenuation of the adrenal mass was \u221216 Hounsfield units (HU). The biochemical evaluation showed potassium of 2.8\u2005mEq\/L (SI unit, mmol\/L) (reference range, 3.5-5.0), plasma aldosterone concentration of 61.3\u2005ng\/dL (SI unit, 1701\u2005pmol\/L) with plasma renin activity of 0.4\u2005ng\/mL\/h (SI unit, \u03bcg\/L\/h). An overnight 1-mg dexamethasone suppression test showed nonsuppressible serum cortisol of 10.8\u2005\u03bcg\/dL (SI unit, 298\u2005nmol\/L). Dehydroepiandrosterone sulfate and ACTH were measured at 24.5\u2005\u03bcg\/dL (age-adjusted, 26-200) (SI unit, 0.66\u2005\u03bcmol\/L; 0.70-5.43) and &amp;lt;5\u2005pg\/mL (SI unit, &amp;lt; 1.1\u2005pmol\/L), respectively. Left adrenalectomy was performed and hydrocortisone therapy was initiated. Postoperatively and thereafter, her blood pressure was controlled with no antihypertensive agent. Seven months later, hydrocortisone therapy was stopped once her cortisol level had normalized. Pathology showed adrenal cortical neoplasm of uncertain malignant potential with associated lipomatous and myelolipomatous metaplasia. This is a rare case of aldosterone and cortisol co-secreting adrenal cortical neoplasm of uncertain malignant potential with lipomatous and myelolipomatous metaplasia. Although the majority of cases of myelolipoma are benign and nonfunctioning, this case emphasizes the importance of thorough hormonal and morphologic evaluation of the tumor.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad012","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T20:29:53Z","timestamp":1677011393000},"source":"Crossref","is-referenced-by-count":3,"title":["Aldosterone- and Cortisol Co-secreting Adrenal Cortical Neoplasm With Lipomatous and Myelolipomatous Metaplasia\u202f\u202f"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3661-2159","authenticated-orcid":false,"given":"Sruthi","family":"Jinna","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Toledo College of Medicine and Life Sciences , Toledo, Ohio 43614 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rokana","family":"Taftaf","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Toledo College of Medicine and Life Sciences , Toledo, Ohio 43614 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas G","family":"Petros","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Toledo College of Medicine and Life Sciences , Toledo, Ohio 43614 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0926-5721","authenticated-orcid":false,"given":"John Y","family":"Jun","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Toledo College of Medicine and Life Sciences , Toledo, Ohio 43614 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"issue":"1","key":"2024010813073579700_luad012-B1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12020-017-1473-4","article-title":"Adrenal myelolipoma: a comprehensive review","volume":"59","author":"Decmann","year":"2018","journal-title":"Endocrine"},{"issue":"2","key":"2024010813073579700_luad012-B2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4158\/EP.15.2.128","article-title":"Adrenocortical neoplasms with myelolipomatous and lipomatous metaplasia: report of 3 cases","volume":"15","author":"Montone","year":"2009","journal-title":"Endocr Pract"},{"issue":"5","key":"2024010813073579700_luad012-B3","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024010813073579700_luad012-B4","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1210\/clinem\/dgaa952","article-title":"Approach to the patient with primary aldosteronism: utility and limitations of adrenal vein sampling","volume":"106","author":"Turcu","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2024010813073579700_luad012-B5","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.2214\/AJR.16.17758","article-title":"Update on CT and MRI of adrenal nodules","volume":"208","author":"Schieda","year":"2017","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"2024010813073579700_luad012-B6","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1530\/ERC-16-0564","article-title":"Lipomatous tumours in adrenal gland: WHO updates and clinical 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