{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:46Z","timestamp":1753883626950,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pheochromocytomas are rare neuroendocrine tumors that may secrete catecholamines, resulting in a wide array of clinical symptoms. While patients classically present with hypertension, headache, diaphoresis, and flushing, these symptoms are present in only 40% of cases. Here, we describe a 70-year-old woman whose predominant symptom was unexplained severe weight loss over a 12-month period associated with fatigue, anxiety, and palpitations at her endocrinologist and geriatrician visits.<\/jats:p>\n               <jats:p>Diagnostic imaging was performed to assess for malignancy and demonstrated a 2.0 cm \u00d7 2.0\u2005cm left adrenal mass. The diagnosis of pheochromocytoma was confirmed by elevated plasma normetanephrine levels. After a 2-week alpha blockade with doxazosin, the patient underwent robotic left adrenalectomy.<\/jats:p>\n               <jats:p>Following surgery, the patient regained weight, and her hypertension also improved significantly. We hope this uncommon clinical presentation in an older adult characterized by weight loss and frailty will increase the awareness of atypical pheochromocytoma symptomatology, particularly in older individuals.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad037","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T12:47:05Z","timestamp":1682081225000},"source":"Crossref","is-referenced-by-count":1,"title":["Unexplained Cachexia as a Presenting Symptom of Pheochromocytoma in a Geriatric Patient"],"prefix":"10.1210","volume":"1","author":[{"given":"Am\u00e9lie","family":"Nkodo","sequence":"first","affiliation":[{"name":"Virginia Commonwealth University School of Medicine , Richmond, VA 23298 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Wu","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University School of Medicine , Richmond, VA 23298 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hobgood","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics, Virginia Commonwealth University School of Medicine , Richmond, VA 23298 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7218-7052","authenticated-orcid":false,"given":"Francesco S","family":"Celi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism, UConn Health , Farmington, CT 06030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"issue":"9","key":"2024010813062926300_luad037-B1","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvac105","article-title":"Systematic review: incidence of pheochromocytoma and paraganglioma over 70 years","volume":"6","author":"Al 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Metab"},{"issue":"4","key":"2024010813062926300_luad037-B6","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1210\/clinem\/dgz314","article-title":"Pheochromocytoma and paraganglioma patients with poor survival often show brown adipose tissue activation","volume":"105","author":"Sater","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024010813062926300_luad037-B7","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s00774-018-0959-3","article-title":"Change of skeletal muscle mass in patients with pheochromocytoma","volume":"37","author":"Lee","year":"2019","journal-title":"J Bone Miner Metab"},{"issue":"10","key":"2024010813062926300_luad037-B8","doi-asserted-by":"crossref","first-page":"e4028","DOI":"10.1210\/clinem\/dgab401","article-title":"Correlation between plasma catecholamines, weight, and diabetes in pheochromocytoma and paraganglioma","volume":"106","author":"Krumeich","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2024010813062926300_luad037-B9","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an Endocrine Society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024010813062926300_luad037-B10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1055\/s-0042-124189","article-title":"Changes in body mass index in pheochromocytoma patients following adrenalectomy","volume":"49","author":"Spyroglou","year":"2017","journal-title":"Horm Metab Res"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/2\/luad037\/51824998\/luad037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/2\/luad037\/51824998\/luad037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T13:25:23Z","timestamp":1704720323000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad037\/7135536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,17]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad037","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2023,2,17]]},"article-number":"luad037"}}