{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:16:32Z","timestamp":1788189392420,"version":"build-2803163510"},"reference-count":10,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Graves\u2019 disease (GD) is an autoimmune condition that affects both thyroid gland lobes. Patients with GD with unilateral thyroid scan uptake are rare. These patients present with classic Graves\u2019 symptoms, occasionally with Graves\u2019 ophthalmopathy characteristics and increased thyroid hormones, and scintigraphic assessment reveals radiotracer uptake in only 1 lobe of the thyroid gland. In this case, a 48-year-old female presented with symptoms and signs indicative of thyrotoxicosis. Laboratory results revealed that TSH was undetectable, whereas free thyroxine and free triiodothyronine were in the high-normal range. Positive results were observed for both thyroid-stimulating Ig and TSH receptor antibodies. Ultrasonography of the thyroid gland revealed an enlarged left lobe with heterogeneous echotexture and a hyperemic gland without any focal lesions, distinct nodules, or cysts. Thyroid scintigraphy revealed enlarged and increased radioisotope uptake in the left lobe and decreased uptake in the right lobe, with no hot or cold nodules. The most likely diagnosis was unilateral GD. The patient was administered carbimazole and within 8 weeks had improved clinically and biochemically.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad048","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T04:41:16Z","timestamp":1684298476000},"source":"Crossref","is-referenced-by-count":4,"title":["Unilateral Graves\u2019 Disease in a Bilobar Thyroid Gland: A Very Unusual Cause of Hyperthyroidism"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-4096","authenticated-orcid":false,"given":"Khaled","family":"Alaybaa","sequence":"first","affiliation":[{"name":"Department of Endocrine, Obesity Endocrine and Metabolic Center, King Fahd Medical City , Riyadh 11525 , Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-0579","authenticated-orcid":false,"given":"Omar","family":"Alhuzaim","sequence":"additional","affiliation":[{"name":"Department of Endocrine, Obesity Endocrine and Metabolic Center, King Fahd Medical City , Riyadh 11525 , Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"issue":"3","key":"2023112320440492500_luad048-B1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/2042018811408488","article-title":"Current concepts in Graves\u2019 disease","volume":"2","author":"Girgis","year":"2011","journal-title":"Therap Adv Endocrinol Metab"},{"issue":"5","key":"2023112320440492500_luad048-B2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/thy.2006.16.493","article-title":"Case history: unilateral Graves\u2019 disease","volume":"16","author":"Bolognesi","year":"2006","journal-title":"Thyroid"},{"issue":"4","key":"2023112320440492500_luad048-B3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1507\/endocrj.50.409","article-title":"Thyroid hemiagenesis with multinodular goiter: a case report and review of the literature","volume":"50","author":"Karabay","year":"2003","journal-title":"Endocr J"},{"issue":"2","key":"2023112320440492500_luad048-B4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02473402","article-title":"Hemiaplasia of the thyroid associated with Graves\u2019 disease: report of three cases and a review of the literature","volume":"24","author":"Ozaki","year":"1994","journal-title":"Surg Today"},{"issue":"3","key":"2023112320440492500_luad048-B5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.14341\/ket2017345-56","article-title":"Review of American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis","volume":"13","author":"Fadeyev","year":"2017","journal-title":"Clin Exp Thyroidol"},{"issue":"11","key":"2023112320440492500_luad048-B6","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/BF03348954","article-title":"Two cases of Graves\u2019 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gland","volume":"21","author":"Chen","year":"2011","journal-title":"Thyroid"},{"issue":"9","key":"2023112320440492500_luad048-B10","first-page":"OD06","article-title":"Unilateral Grave's disease: a rare variant","volume":"13","author":"Pande","year":"2019","journal-title":"J Clin Diagnostic Res"}],"container-title":["JCEM Case 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