{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:03Z","timestamp":1753883523801,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin D is one of the most commonly recommended dietary supplements and is often the first medication ever prescribed in infancy. However, with the variety of concentrations available, including many over-the-counter formulations, dosing errors can easily occur. We present a case of a breastfed infant with a calcium level greater than 23\u2005mg\/dL (5.75\u2005mmol\/L), whose severe hypercalcemia was due to hypervitaminosis D from accidentally overdosed vitamin D supplementation. We consider the differential diagnosis for her presentation and review the interventions required for treatment of her hypercalcemia. Notably, we reinforce the importance of carefully reviewing dosing of vitamin D supplementation with families. We also discuss the management of hypercalcemia, including the role of fluids, diuretics, and glucocorticoids, as well as the long-term sequalae of severe hypercalcemia.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad049","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T11:46:31Z","timestamp":1684323991000},"source":"Crossref","is-referenced-by-count":0,"title":["Severe Hypercalcemia due to Hypervitaminosis D in a Breastfed Infant"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-5651","authenticated-orcid":false,"given":"Julie R","family":"Barzilay","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Boston Children\u2019s Hospital, Harvard Medical School , Boston, MA 02115 , USA"},{"name":"Department of Pediatrics, Boston Medical Center , Boston, MA 02119 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-323X","authenticated-orcid":false,"given":"Raymond J","family":"Kreienkamp","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Boston Children's Hospital, Harvard Medical School , Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3212-6180","authenticated-orcid":false,"given":"Rebecca J","family":"Gordon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Boston Children's Hospital, Harvard Medical School , Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"issue":"6","key":"2023112320434561600_luad049-B1","first-page":"745","article-title":"Vitamin D supplementation in infants, children, and 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supplements","volume":"10","author":"G\u00e9rard","year":"2022","journal-title":"Front Pediatr"},{"issue":"355","key":"2023112320434561600_luad049-B5","first-page":"e1","article-title":"Infant nephrolithiasis and nephrocalcinosis: natural history and predictors of surgical intervention","volume":"13","author":"Andrioli","year":"2017","journal-title":"J Pediatr Urol"},{"issue":"1","key":"2023112320434561600_luad049-B6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12882-017-0505-x","article-title":"Epidemiology of paediatric renal stone disease: a 22-year single centre experience in the UK","volume":"18","author":"Isslar","year":"2017","journal-title":"BMC Nephrol"},{"issue":"9","key":"2023112320434561600_luad049-B7","first-page":"1959","article-title":"A practical approach to 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