{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:06Z","timestamp":1753883526302,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Graves\u2019 disease is the most common cause of pediatric hyperthyroidism and thyrotoxicosis. Thyroid storm is a rare initial manifestation of Graves\u2019 disease and represents an endocrine emergency. We report a case of transient hyperthyroidism, possibly a paraneoplastic syndrome presenting as impending thyroid storm in a patient with undiagnosed hepatoblastoma. To our knowledge, this is the first case of this association reported in children. A previously healthy 21-month-old male presented with abdominal pain and unremitting tachycardia. He was managed for thyrotoxicosis and impending thyroid storm. He subsequently was found to have hepatomegaly leading to a diagnosis of hepatoblastoma. Autoimmune markers for Graves\u2019 disease were negative, along with a negative human chorionic gonadotropin. After initiation of neoadjuvant chemotherapy, he had complete resolution of thyrotoxicosis. Paraneoplastic syndromes may occur with any tumor. We present a unique case of a patient developing human chorionic gonadotropin-negative hyperthyroidism, possibly as a paraneoplastic syndrome from hepatoblastoma.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad051","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T10:06:30Z","timestamp":1686823590000},"source":"Crossref","is-referenced-by-count":0,"title":["Thyrotoxicosis and Impending Thyroid Storm: A Rare Paraneoplastic Syndrome in an Infant With Hepatoblastoma"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9688-0740","authenticated-orcid":false,"given":"Neha","family":"Vyas","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Nemours Children's Health , Orlando, FL 32827 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arino","family":"Neto","sequence":"additional","affiliation":[{"name":"Pediatrics Residency Program, Department of Pediatrics, Nemours Children's Health , Orlando, FL 32827 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauri","family":"Carakushansky","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Nemours Children's Health , Orlando, FL 32827 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Gurnurkar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Nemours Children's Health , Orlando, FL 32827 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"issue":"6","key":"2023061510062233800_luad051-B1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1542\/pir.36.6.239","article-title":"Hyperthyroidism in children","volume":"36","author":"Srinivasan","year":"2015","journal-title":"Pediatr Rev"},{"key":"2023061510062233800_luad051-B2","article-title":"Thyrotoxic crisis as an acute clinical presentation in a child","volume":"2018","author":"Bonfield","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2023061510062233800_luad051-B3","first-page":"608","volume-title":"Diagnostic Ultrasound: Text and Cases","author":"Cole-Beuglet","year":"1987","edition":"2nd ed."},{"issue":"10","key":"2023061510062233800_luad051-B4","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 American Thyroid Association Guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis [published correction appears in Thyroid. 2017 Nov; 27(11):1462]","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"issue":"1","key":"2023061510062233800_luad051-B5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1089\/thy.2018.0275","article-title":"National trends in incidence, mortality, and clinical outcomes of patients hospitalized for thyrotoxicosis with and without thyroid storm in the United States, 2004\u20132013","volume":"29","author":"Galindo","year":"2019","journal-title":"Thyroid"},{"issue":"2","key":"2023061510062233800_luad051-B6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.emc.2013.12.001","article-title":"Hyperthyroidism and thyrotoxicosis","volume":"32","author":"Devereaux","year":"2014","journal-title":"Emerg Med Clin North Am"},{"issue":"12","key":"2023061510062233800_luad051-B7","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1507\/endocrj.EJ16-0336","article-title":"2016 Guidelines for the management of thyroid storm from the Japan Thyroid Association and Japan Endocrine Society (First edition)","volume":"63","author":"Satoh","year":"2016","journal-title":"Endocr J"},{"issue":"9","key":"2023061510062233800_luad051-B8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.4065\/mcp.2010.0099","article-title":"Paraneoplastic syndromes: an approach to diagnosis and treatment [published correction appears in Mayo Clin Proc. 2011; 86(4):364. Dosage error in article text]","volume":"85","author":"Pelosof","year":"2010","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"2023061510062233800_luad051-B9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1053\/j.semdp.2016.12.015","article-title":"Hepatoblastoma","volume":"34","author":"Sharma","year":"2017","journal-title":"Semin Diagn Pathol"},{"issue":"6","key":"2023061510062233800_luad051-B10","first-page":"330","article-title":"Human chorionic gonadotropin-induced hyperthyroidism in germ cell cancer\u2013a case presentation and review of the literature","volume":"30","author":"Voigt","year":"2007","journal-title":"Onkologie"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/3\/luad051\/50614224\/luad051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/3\/luad051\/50614224\/luad051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T10:06:41Z","timestamp":1686823601000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad051\/7198289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5,8]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad051","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,5]]},"article-number":"luad051"}}