{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:07:54Z","timestamp":1772579274417,"version":"3.50.1"},"reference-count":10,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An 8-year, 7-month-old male presented with puberty symptoms, including a 1.5-year history of facial hair with 9 months of phallic growth, body odor, and acne. Physical examination revealed phallic enlargement but only 4\u2005mL testes bilaterally. Laboratory evaluation revealed markedly elevated LH and testosterone, but a prepubertal FSH level and minimally elevated adrenal androgens. A magnetic resonance imaging scan of the head revealed an anterior pituitary adenoma, and after the patient failed to respond to leuprolide, he was initiated on spironolactone and anastrozole to minimize pubertal progression before transsphenoidal adenomectomy. Postoperatively, the patient had rapid reduction of LH and testosterone, with subsequent cessation of pubertal progression, confirming the diagnosis of an LH-secreting pituitary adenoma despite negative immunoreactivity for LH and FSH. Functioning gonadotroph adenomas are rare and have been documented only in small case series and case reports. When active, these most commonly secrete FSH or co-secrete FSH and LH, and only very rarely result in precocious puberty. Here, we describe a rare case of an isolated LH-secreting functioning gonadotroph adenoma resulting in precocious puberty. This case reinforces the need to critically analyze departures from the typical pubertal sequence and to expand one's differential to include etiologies that can cause unbalanced secretion of gonadotropins.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad055","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T10:06:29Z","timestamp":1686823589000},"source":"Crossref","is-referenced-by-count":3,"title":["A Rare Case of Precocious Puberty Secondary to an LH-secreting Pituitary Adenoma"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-7314","authenticated-orcid":false,"given":"Anna","family":"Uhing","sequence":"first","affiliation":[{"name":"School of Medicine and Public Health, Department of Pediatrics, University of Wisconsin , Madison, WI 53792 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam","family":"Ahmed","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, Department of Neurological Surgery, University of Wisconsin , Madison, WI 53792 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahriar","family":"Salamat","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, Department of Pathology, University of Wisconsin , Madison, WI 53792 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, Department of Pediatrics, University of Wisconsin , Madison, WI 53792 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"issue":"6","key":"2023061510062144400_luad055-B1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199019","article-title":"Central precocious puberty in Boston boys: a 10-year single center 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and prolactin by a pituitary adenoma","volume":"102","author":"Faggiano","year":"1983","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"suppl 1","key":"2023061510062144400_luad055-B9","first-page":"952","article-title":"Endocrine Society's 97th Annual Meeting and Expo, March 5\u20138, 2015, San Diego, CA","volume":"36","author":"Kadakia","year":"2015","journal-title":"Endocr Rev"},{"issue":"6","key":"2023061510062144400_luad055-B10","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1227\/NEU.0000000000001188","article-title":"Functional gonadotroph adenomas: case series and report of literature","volume":"79","author":"Cote","year":"2016","journal-title":"Neurosurgery"}],"container-title":["JCEM Case 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