{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:04Z","timestamp":1753883584361,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Management options for benign, autonomously functioning, and malignant thyroid nodules were limited to surgery or targeting by radioactive iodine before the availability of radiofrequency ablation (RFA). Despite being a relatively new technique, RFA may be favored for patients of high surgical risk, and for those who wish to avoid hypothyroidism. Although insurance coverage for the procedure can be a significant barrier, several groups of investigators have shown improved quality of life for RFA compared to surgery, due to the less invasive nature and favorable risk profile. Hyperthyroidism due to transient thyroiditis is a known risk of RFA, secondary to direct trauma and subsequent thyroid hormone release. Here we present a case of an adult with large, symptomatic, multinodular goiter, with no prior history of thyroid autoimmunity, who underwent RFA with successful volume reduction of two nodules, but who developed acute hyperthyroidism due to Graves disease eight weeks after RFA. Larger studies evaluating the risks of RFA should evaluate for incident hyperthyroidism, specifically for Graves disease\/thyroid autoimmunity, as this could represent an additional risk of the procedure.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad056","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T04:03:22Z","timestamp":1686197002000},"source":"Crossref","is-referenced-by-count":7,"title":["Hyperthyroidism Due to Graves Disease After Radiofrequency Ablation"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-4663","authenticated-orcid":false,"given":"Elizabeth A","family":"McAninch","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Gerontology and Metabolism, Stanford University Medical Center , Stanford, CA 94305 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaniksha","family":"Desai","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Gerontology and Metabolism, Stanford University Medical Center , Stanford, CA 94305 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen C","family":"McCowen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, University of California San Diego , San Diego, CA 92093 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A","family":"Orloff","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Stanford University Medical Center , Stanford, CA 94305 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"issue":"3","key":"2023060804031300100_luad056-B1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/hed.26960","article-title":"Radiofrequency ablation and related ultrasound-guided ablation technologies for treatment of benign and malignant thyroid disease: an international multidisciplinary consensus statement of the American Head and Neck Society Endocrine Surgery Section with the Asia Pacific Society of Thyroid Surgery, Associazione Medici Endocrinologi, British Association of Endocrine and Thyroid Surgeons, European Thyroid Association, Italian Society of Endocrine Surgery Units, Korean Society of Thyroid Radiology, Latin American Thyroid Society, and Thyroid Nodules Therapies Association","volume":"44","author":"Orloff","year":"2022","journal-title":"Head Neck"},{"key":"2023060804031300100_luad056-B2","doi-asserted-by":"crossref","first-page":"619841","DOI":"10.3389\/fendo.2020.619841","article-title":"The recovery of thyroid function in low-risk papillary thyroid cancer after lobectomy: a 3-year follow-up study","volume":"11","author":"Dou","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2023060804031300100_luad056-B3","doi-asserted-by":"crossref","first-page":"37838","DOI":"10.1038\/srep37838","article-title":"Quality of life and cost-effectiveness of radiofrequency ablation versus open surgery for benign thyroid nodules: a retrospective cohort study","volume":"6","author":"Yue","year":"2016","journal-title":"Sci Rep"},{"issue":"7","key":"2023060804031300100_luad056-B4","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3174\/ajnr.A4276","article-title":"Treatment of benign thyroid nodules: comparison of surgery with radiofrequency ablation","volume":"36","author":"Che","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"issue":"1","key":"2023060804031300100_luad056-B5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/02656736.2018.1487590","article-title":"Patient satisfaction after thyroid RFA versus surgery for benign thyroid nodules: a telephone survey","volume":"35","author":"Bernardi","year":"2018","journal-title":"Int J Hyperthermia"},{"issue":"1","key":"2023060804031300100_luad056-B6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1080\/02656736.2021.1950849","article-title":"Thyroid dysfunction following radiofrequency ablation for benign thyroid nodules: more likely to occur within one-week and in high-risk population","volume":"38","author":"Wang","year":"2021","journal-title":"Int J Hyperthermia"},{"issue":"2","key":"2023060804031300100_luad056-B7","doi-asserted-by":"crossref","first-page":"100824","DOI":"10.1016\/j.tvir.2022.100824","article-title":"Thyroid nodule radiofrequency ablation: complications and clinical follow up","volume":"25","author":"Lim","year":"2022","journal-title":"Tech Vasc Interv Radiol"},{"issue":"3","key":"2023060804031300100_luad056-B8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s12020-020-02598-6","article-title":"Radiofrequency ablation and thyroid nodules: updated systematic review","volume":"72","author":"Muhammad","year":"2021","journal-title":"Endocrine"},{"issue":"2","key":"2023060804031300100_luad056-B9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1089\/thy.2011.0315","article-title":"Severe Graves\u2019 ophthalmopathy after percutaneous ethanol injection in a nontoxic thyroid nodule","volume":"22","author":"Regalbuto","year":"2012","journal-title":"Thyroid"},{"issue":"6","key":"2023060804031300100_luad056-B10","doi-asserted-by":"crossref","first-page":"512","DOI":"10.4158\/EP-2018-0059","article-title":"Positive thyrotropin receptor antibodies in patients with transient thyrotoxicosis","volume":"24","author":"Angell","year":"2018","journal-title":"Endocr Pract"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/3\/luad056\/50536793\/luad056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/3\/luad056\/50536793\/luad056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T04:03:27Z","timestamp":1686197007000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad056\/7191875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5,8]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad056","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,5]]},"article-number":"luad056"}}