{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:03:13Z","timestamp":1787241793201,"version":"build-2736575974"},"reference-count":10,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adrenal cortical carcinoma (ACC) is a rare cancer (1-2\/million) that presents with hormone overproduction in 60% of cases. Presentation of ACC with multiple hormone syndromes from different adrenal zones is rare. We present a case of dual-secreting ACC with hyperaldosteronism and cortisol excess. The previously healthy patient was noted to have new-onset hypertension and hypokalemia during a primary care visit. On hormonal evaluation, he was found to have evidence of hyperaldosteronism and adrenocorticotropic hormone (ACTH)-independent cortisol excess. Imaging revealed a 2.7 \u00d7 3.1 \u00d7 3.5\u2005cm left adrenal mass with indeterminant computed tomography characteristics. He underwent laparoscopic adrenalectomy and required glucocorticoid replacement for adrenal insufficiency postoperatively. Pathology revealed stage T2N0M0 ACC. His hypokalemia resolved and glucocorticoids were stopped within a month. This case stresses the importance of routine screening for cortisol excess in all adrenal masses detected on imaging. Avoidance of postoperative adrenal insufficiency in patients with cortisol excess without overt Cushing syndrome is paramount.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad073","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T16:52:45Z","timestamp":1686243165000},"source":"Crossref","is-referenced-by-count":5,"title":["Dual Aldosterone- and Cortisol-Secreting Adrenal Cortical Carcinoma: Pre- and Perioperative Evaluation and Management"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3845-5791","authenticated-orcid":false,"given":"Rebecca","family":"Rosenberg","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Anschutz Medical Campus , Aurora, CO, USA 80045"},{"name":"Department of Veterans Affairs, Rocky Mountain Regional Veterans Medical Center , Aurora, CO, USA 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D","family":"Raeburn","sequence":"additional","affiliation":[{"name":"Division of GI, Trauma and Endocrine Surgery, University of Colorado Anschutz Medical Campus , Aurora, CO, USA 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Clay","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Anschutz Medical Campus , Aurora, CO, USA 80045"},{"name":"Department of Pathology, University of Colorado School of Medicine , Aurora, CO, USA 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-1093","authenticated-orcid":false,"given":"Margaret E","family":"Wierman","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Anschutz Medical Campus , Aurora, CO, USA 80045"},{"name":"Department of Veterans Affairs, Rocky Mountain Regional Veterans Medical Center , Aurora, CO, USA 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"issue":"11","key":"2023071204512560600_luad073-B1","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1210\/clinem\/dgab512","article-title":"Approach to the patient with adrenal incidentaloma","volume":"106","author":"Bancos","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2023071204512560600_luad073-B2","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1210\/jc.2005-2730","article-title":"Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients","volume":"91","author":"Abiven","year":"2006","journal-title":"J Clin Endocrinol 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