{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:59:47Z","timestamp":1780498787518,"version":"3.54.1"},"reference-count":9,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypopituitarism due to an internal carotid artery (ICA) aneurysm is rare. We present a case of hypopituitarism and hyperprolactinemia due to a giant right ICA aneurysm. A 56-year-old woman with a history of primary hypothyroidism presented with fatigue, right-sided headache, and blurred vision. Magnetic resonance (MR) of the brain revealed a sellar mass measuring 3.5 \u00d7 2.2 cm involving the right cavernous sinus. Initial neurologic examination was unremarkable, and her biochemical evaluation revealed secondary adrenal insufficiency, central hypogonadism, low serum free thyroxine, and mildly elevated serum prolactin, consistent with stalk effect. Hydrocortisone therapy was started for secondary adrenal insufficiency and her levothyroxine dose was adjusted. The patient was referred to neurosurgery for surgical management of her sellar lesion. Preoperative computed tomography angiography (CTA) of the brain revealed a right ICA aneurysm that contacted the optic chiasm and displaced the pituitary gland. The aneurysm was embolized and diverting stents were placed. Repeat laboratory tests showed resolution of the patient's secondary adrenal insufficiency, normalization of serum prolactin, and an increase in serum gonadotropin concentrations to the postmenopausal range. This case highlights that not all sellar lesions are pituitary adenomas, and CTA should be performed in the evaluation of large cavernous sinus lesions to exclude ICA aneurysm.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad076","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T10:39:46Z","timestamp":1688207986000},"source":"Crossref","is-referenced-by-count":2,"title":["Internal Carotid Artery Aneurysm Disguised as Pituitary Macroadenoma"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6661-1267","authenticated-orcid":false,"given":"Neha","family":"Mulpuri","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, UT Southwestern Medical Center , Dallas, TX 75390 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans K","family":"Ghayee","sequence":"additional","affiliation":[{"name":"Malcom Randall VA Medical Center, Division of Endocrinology & Metabolism, University of Florida , Gainesville, FL 32608 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Abramowitz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Metabolism, UT Southwestern Medical Center , Dallas, TX 75390 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4251-5737","authenticated-orcid":false,"given":"Sasan","family":"Mirfakhraee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Metabolism, UT Southwestern Medical Center , Dallas, TX 75390 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"issue":"8","key":"2023070110394152200_luad076-B1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0025-6196(11)63222-9","article-title":"Hypopituitarism caused by intrasellar aneurysms","volume":"76","author":"Heshmati","year":"2001","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"2023070110394152200_luad076-B2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3171\/2011.9.JNS11380","article-title":"Cerebral aneurysms with intrasellar extension: a systematic review of clinical, anatomical, and treatment characteristics","volume":"116","author":"Hanak","year":"2012","journal-title":"J Neurosurg"},{"issue":"3","key":"2023070110394152200_luad076-B3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00005072-195807000-00001","article-title":"A systematic analysis of intracranial aneurysms from the autopsy file of the Presbyterian Hospital, 1914 to 1956","volume":"17","author":"Housepian","year":"1958","journal-title":"J Neuropathol Exp Neurol"},{"issue":"5","key":"2023070110394152200_luad076-B4","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1227\/00006123-198205000-00011","article-title":"Reversible panhypopituitarism caused by a suprasellar aneurysm: the contribution of mass effect to pituitary dysfunction","volume":"10","author":"Verbalis","year":"1982","journal-title":"Neurosurgery"},{"key":"2023070110394152200_luad076-B5","doi-asserted-by":"crossref","first-page":"536191","DOI":"10.1155\/2015\/536191","article-title":"Pituitary insufficiency and hyperprolactinemia associated with giant intra- and suprasellar carotid artery aneurysm","volume":"2015","author":"Gungor","year":"2015","journal-title":"Case Rep Med"},{"issue":"1","key":"2023070110394152200_luad076-B6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0090-3019(83)90110-6","article-title":"Rupture of anterior communicating artery aneurysm during transsphenoidal surgery for pituitary adenoma","volume":"20","author":"Tsuchida","year":"1983","journal-title":"Surg Neurol"},{"issue":"1","key":"2023070110394152200_luad076-B7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13104-018-3329-2","article-title":"Intra cavernous aneurysm of internal carotid artery masquerading as a pituitary adenoma: a case report","volume":"11","author":"Wijethunga","year":"2018","journal-title":"BMC Res Notes"},{"issue":"5","key":"2023070110394152200_luad076-B8","first-page":"333","article-title":"Endocrinologic recovery after treatment of an intrasellar aneurysm [article in French]","volume":"48","author":"Slaba","year":"2000","journal-title":"J Med Liban"},{"issue":"6","key":"2023070110394152200_luad076-B9","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1136\/neurintsurg-2014-011233.rep","article-title":"Recovery of pituitary function following treatment of an unruptured giant cavernous carotid aneurysm using surpass flow-diverting stents","volume":"7","author":"Tan","year":"2015","journal-title":"J Neurointerv Surg"}],"container-title":["JCEM Case 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