{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:38Z","timestamp":1753883618815,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gallbladder disease is one of the most common gastrointestinal tract diseases. In obstructive jaundice, there is a reduction in bile flow out of the liver secondary to the blocked bile or pancreatic duct, which leads to excess bile and its products accumulating in the blood. One of these products is lipoprotein X (LpX); its presence is associated with a lipoprotein pattern characterized by an increased concentration of low-density lipoprotein (LDL) cholesterol. Few published articles have reported the association between obstructive jaundice and hyperlipidemia. This report describes a unique case of a Saudi female patient diagnosed with obstructive jaundice, presenting with extreme hypercholesterolemia, which was reduced significantly 1 week after endoscopic retrograde cholangiopancreatography (ERCP). Correct recognition and investigation of the lipid profile are important for differentiating LpX-mediated hypercholesterolemia caused by obstructive jaundice from other causes of elevated LDL concentrations. Differentiation may affect the patient's therapeutic management.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad080","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T06:47:20Z","timestamp":1689144440000},"source":"Crossref","is-referenced-by-count":0,"title":["Significant High Lipid Profile in a Woman With Obstructive Jaundice"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1024-2663","authenticated-orcid":false,"given":"Mashael","family":"Albargawi","sequence":"first","affiliation":[{"name":"Adult Endocrinology Department, King Saud Medical City , Riyadh 12746 , Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8473-6991","authenticated-orcid":false,"given":"Ibtihal","family":"Abdulaal","sequence":"additional","affiliation":[{"name":"Adult Endocrinology Department, King Saud Medical City , Riyadh 12746 , Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"issue":"24","key":"2023071204513516400_luad080-B1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.amsu.2019.04.003","article-title":"Comparative analysis of serum lipid profiles in patients with and without gallstones: a prospective cross-sectional study","volume":"42","author":"Hayat","year":"2019","journal-title":"Ann Med Surg (Lond)"},{"issue":"4","key":"2023071204513516400_luad080-B2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/1751-2980.12857","article-title":"Prevalence and risk factors for gallstone disease: a population-based cross-sectional study","volume":"21","author":"Song","year":"2020","journal-title":"J Dig Dis"},{"issue":"1","key":"2023071204513516400_luad080-B3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0889-8553(05)70045-5","article-title":"Gallstone formation: local factors","volume":"28","author":"Ko","year":"1999","journal-title":"Gastroenterol Clin North Am"},{"issue":"7905","key":"2023071204513516400_luad080-B4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0140-6736(75)92831-7","article-title":"Gallbladder disease in hyperlipoprotein\u00e6mia","volume":"305","author":"Einarsson","year":"1975","journal-title":"Lancet"},{"issue":"5","key":"2023071204513516400_luad080-B5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5551\/jat.E559","article-title":"A case of obstructive jaundice with severe hypercholesterolemia probably due to lipoprotein-Y","volume":"15","author":"Murano","year":"2008","journal-title":"J Atheroscler Thromb"},{"issue":"6","key":"2023071204513516400_luad080-B6","first-page":"e5","article-title":"Hyperlipidemia in the presence of painless obstructive jaundice secondary to pancreatic cancer","volume":"61","author":"Haider","year":"2021","journal-title":"Consultant"},{"issue":"3389","key":"2023071204513516400_luad080-B7","doi-asserted-by":"crossref","first-page":"969081","DOI":"10.3389\/fped.2022.969081","article-title":"Case report: unusual and extremely severe lipoprotein X-mediated hypercholesterolemia in extrahepatic pediatric cholestasis","volume":"10","author":"Colantuono","year":"2022","journal-title":"Front Pediatr"},{"issue":"7","key":"2023071204513516400_luad080-B8","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1172\/JCI106085","article-title":"A lipoprotein characterizing obstructive jaundice. 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Method for quantitative separation and identification of lipoproteins in jaundiced subjects","volume":"48","author":"Seidel","year":"1969","journal-title":"J Clin Invest"},{"key":"2023071204513516400_luad080-B9","article-title":"Pseudohyponatraemia secondary to hyperlipidaemia in obstructive jaundice","volume":"2017","author":"Igbinedion","year":"2017","journal-title":"BMJ Case Rep"},{"issue":"1016","key":"2023071204513516400_luad080-B10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.clinbiochem.2021.04.017","article-title":"Clinical laboratory characteristics of patients with obstructive jaundice accompanied by dyslipidemia","volume":"94","author":"Zhao","year":"2021","journal-title":"Clin Biochem"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/4\/luad080\/50857015\/luad080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/4\/luad080\/50857015\/luad080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T06:47:29Z","timestamp":1689144449000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad080\/7222978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad080","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2023,7]]},"published":{"date-parts":[[2023,7,1]]},"article-number":"luad080"}}