{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:20:27Z","timestamp":1756462827237,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome associated with tumors secreting fibroblast growth factor 23 that can be cured with complete surgical resection of the tumor. However, when these tumors are at difficult locations, less invasive modalities such as thermal ablation (TA) might be a good alternative. A 40-year-old woman was seen for a second opinion because of severe hypophosphatemia with complaints of fatigue, myalgia, and muscle weakness for which she needed IV phosphate for 15 to 18\u2005hours per day in addition to oral alfacalcidol and phosphate. Initial laboratory results revealed hypophosphatemia (0.59\u2005mmol\/L [1.83\u2005mg\/dL]; reference range, 0.90-1.50\u2005mmol\/L [8.40-10.2\u2005mg\/dL]), increased fibroblast growth factor 23 levels (137 RU\/mL; reference range, &amp;lt;125\u2005RU\/mL), and a reduced TmP-GFR (0.47\u2005mmol\/L; reference range, 0.8-1.4\u2005mmol\/L). Gallium-positron emission tomography\/computed tomography (CT) showed moderately increased uptake at thoracic vertebra (Th) 8 and mildly increased uptake at Th7, suggestive of TIO. Complete tumor removal would have required resection of at least 1 vertebral body. Therefore, CT-guided TA was performed at Th8. No complications were observed, and in the months after, treatment with IV phosphate could be discontinued, indicating a satisfying result from the procedure. This extreme TIO case demonstrates that CT-guided TA can be an alternative to extensive or risky classical surgery.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad086","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T18:36:01Z","timestamp":1690482961000},"source":"Crossref","is-referenced-by-count":2,"title":["Thermal Ablation for Treating Tumor-induced Osteomalacia in a Patient With IV Phosphate Dependency"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-065X","authenticated-orcid":false,"given":"Evert F S","family":"van Velsen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Erasmus University Medical Center , 3015 CE, Rotterdam , The Netherlands"},{"name":"Erasmus MC Bone Center, Erasmus University Medical Center , 3015 CE, Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tychon E A","family":"Geeraedts","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Erasmus University Medical Center , 3015 CE, Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7466-1472","authenticated-orcid":false,"given":"Ariadne","family":"Bosman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus University Medical Center , 3015 CE, Rotterdam , The Netherlands"},{"name":"Erasmus MC Bone Center, Erasmus University Medical Center , 3015 CE, Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Carola","family":"Zillikens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus University Medical Center , 3015 CE, Rotterdam , The Netherlands"},{"name":"Erasmus MC Bone Center, Erasmus University Medical Center , 3015 CE, Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"issue":"4","key":"2023072718135071800_luad086-B1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00223-022-01005-8","article-title":"Tumor-induced osteomalacia: a systematic clinical review of 895 cases","volume":"111","author":"Bosman","year":"2022","journal-title":"Calcif Tissue Int"},{"issue":"8","key":"2023072718135071800_luad086-B2","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/1097-0142(19870415)59:8<1442::AID-CNCR2820590810>3.0.CO;2-Q","article-title":"Phosphaturic mesenchymal tumors. 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