{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:51:41Z","timestamp":1753883501789,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lithium is not commonly used to treat thyrotoxicosis, and there are few reports in the literature of its use as initial therapy in thyrotoxicosis. We describe the case of a patient with Graves thyrotoxicosis and ophthalmopathy, on a background of autoimmune neutropenia, treated successfully with relatively long-term lithium monotherapy. Lithium was used at a lower dose and longer duration than previously reported on, to good effect. We demonstrate that lithium is an important and useful option for those who are unable to tolerate thionamide therapy.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad094","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T18:36:08Z","timestamp":1690482968000},"source":"Crossref","is-referenced-by-count":0,"title":["Lithium Monotherapy in Graves Thyrotoxicosis"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-9953","authenticated-orcid":false,"given":"James","family":"Larkworthy","sequence":"first","affiliation":[{"name":"Department of Endocrinology & Diabetes, University Hospitals Sussex NHS Foundation Trust , Brighton, BN2 5BE , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0708-1571","authenticated-orcid":false,"given":"Omar","family":"Kirresh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Diabetes, University Hospitals Sussex NHS Foundation Trust , Brighton, BN2 5BE , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-8363","authenticated-orcid":false,"given":"Ali","family":"Chakera","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Diabetes, University Hospitals Sussex NHS Foundation Trust , Brighton, BN2 5BE , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahad","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Diabetes, University Hospitals Sussex NHS Foundation Trust , Brighton, BN2 5BE , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"issue":"1","key":"2023072718135117100_luad094-B1","first-page":"349","article-title":"Diagnosis and management of thyrotoxicosis","volume":"1","author":"Vaidya","year":"2014","journal-title":"BMJ"},{"issue":"5","key":"2023072718135117100_luad094-B2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1365-2265.2004.02135.x","article-title":"Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK","volume":"61","author":"Pearce","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"year":"2019","author":"NICE","key":"2023072718135117100_luad094-B3"},{"issue":"1","key":"2023072718135117100_luad094-B4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0304-4165(78)90242-8","article-title":"Studies on the mechanism of inhibition of thyroid function by lithium","volume":"542","author":"Bagchi","year":"1978","journal-title":"Biochim Biophys Acta"},{"issue":"7960","key":"2023072718135117100_luad094-B5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0140-6736(76)90414-1","article-title":"Lithium carbonate in the treatment of thyrotoxicosis. A controlled trial","volume":"1","author":"Kristensen","year":"1976","journal-title":"Lancet"},{"issue":"2","key":"2023072718135117100_luad094-B6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0025-5564(84)90116-0","article-title":"Perturbations of iodine metabolism by lithium","volume":"72","author":"Robbins","year":"1984","journal-title":"Math Biosci"},{"issue":"2","key":"2023072718135117100_luad094-B7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000112975","article-title":"The use of lithium carbonate in the preparation for definitive therapy in hyperthyroid patients","volume":"17","author":"Akin","year":"2008","journal-title":"Med Princ Pract"},{"issue":"1","key":"2023072718135117100_luad094-B8","first-page":"576","article-title":"Lithium carbonate in the treatment of Graves\u2019 disease with ATD-induced hepatic injury or leukopenia","volume":"1","author":"Zheng","year":"2015","journal-title":"Int J Endocrinol"},{"issue":"1","key":"2023072718135117100_luad094-B9","article-title":"Lithium as an alternative option in Graves thyrotoxicosis","volume":"1","author":"Prakash","year":"2015","journal-title":"Case Rep Endocrinol"},{"issue":"4","key":"2023072718135117100_luad094-B10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/07435800.2021.1924769","article-title":"Meta-analysis of randomized controlled trials comparing the efficacy of radioactive iodine monotherapy versus radioactive iodine therapy and adjunctive lithium for the treatment of hyperthyroidism","volume":"46","author":"Ahmed","year":"2021","journal-title":"Endocr Res"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/4\/luad094\/50977465\/luad094.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/4\/luad094\/50977465\/luad094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T18:36:18Z","timestamp":1690482978000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad094\/7232441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad094","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2023,7]]},"published":{"date-parts":[[2023,7,1]]},"article-number":"luad094"}}