{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:54:16Z","timestamp":1777294456085,"version":"3.51.4"},"reference-count":10,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Primary pituitary T-lymphoblastic lymphoma is a rare clinical entity. A 45-year-old woman presented with headache, left-eye blurry vision, diplopia, ophthalmoplegia, and ptosis. Magnetic resonance imaging of the brain showed a sellar mass most likely consistent with a pituitary macroadenoma. Laboratory evaluation disclosed secondary hypothyroidism, secondary adrenal insufficiency, and hyperprolactinemia. The mass was removed by transsphenoidal resection, and subsequent immunophenotyping revealed T-cell lymphoblastic lymphoma. Secondary workup confirmed lymphomatous confinement to the central nervous system. Following resection, the patient's headaches improved, but she experienced persistent visual deficits and palsies of cranial nerves III, IV, and VI. The chemotherapy regimen consisted of high-dose methotrexate, followed by alternating cycles of cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), dexamethasone (cyclophosphamide, mesna, vincristine sulfate, doxorubicin hydrochloride, dexamethasone), and methotrexate\/cytarabine. Since receiving chemotherapy, there has been an improvement in numbness, ptosis, left orbital pressure, and headaches. This case represents only the eighth example of T-cell primary pituitary lymphoma, and the youngest patient to receive the diagnosis.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad097","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:12:30Z","timestamp":1693563150000},"source":"Crossref","is-referenced-by-count":3,"title":["T-cell Lymphoblastic Lymphoma Presenting as a Pituitary Mass"],"prefix":"10.1210","volume":"1","author":[{"given":"Padmini","family":"Sreedhara","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Kansas School of Medicine, Kansas City, KS 66204, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Czerwinski","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Kansas School of Medicine, Kansas City, KS 66204, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-9312","authenticated-orcid":false,"given":"Ethan","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, Diabetes, Clinical Pharmacology, University of Kansas School of Medicine, Kansas City, KS 66204, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitra","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, Diabetes, Clinical Pharmacology, University of Kansas School of Medicine, Kansas City, KS 66204, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"issue":"3","key":"2023112320450283800_luad097-B1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3171\/JNS-07\/09\/0660","article-title":"Extranodal NK\/T-cell lymphoma presenting as a pituitary mass. Case report and review of the literature","volume":"107","author":"Liu","year":"2007","journal-title":"J Neurosurg"},{"issue":"1","key":"2023112320450283800_luad097-B2","first-page":"53","article-title":"A case of sellar T cell type malignant lymphoma","volume":"26","author":"Sakakibara","year":"1998","journal-title":"No Shinkei Geka"},{"issue":"3","key":"2023112320450283800_luad097-B3","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41375-019-0618-2","article-title":"ATM activity in T cells is critical for immune surveillance of lymphoma in vivo","volume":"34","author":"Riabinska","year":"2020","journal-title":"Leukemia"},{"issue":"3","key":"2023112320450283800_luad097-B4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s004010050990","article-title":"Intrasellar malignant lymphoma developing within pituitary adenoma","volume":"97","author":"Kuhn","year":"1999","journal-title":"Acta Neuropathol"},{"issue":"5","key":"2023112320450283800_luad097-B5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1001\/jama.2016.19699","article-title":"Diagnosis and treatment of pituitary adenomas: a review","volume":"317","author":"Molitch","year":"2017","journal-title":"JAMA"},{"issue":"5","key":"2023112320450283800_luad097-B6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1507\/endocrj.52.543","article-title":"Primary pituitary lymphoma presenting as hypophysitis","volume":"52","author":"Huang","year":"2005","journal-title":"Endocr J"},{"key":"2023112320450283800_luad097-B7","author":"Spina","year":"2000"},{"issue":"8","key":"2023112320450283800_luad097-B8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00701-008-1585-y","article-title":"Precursor T-lymphoblastic lymphoma within a recurrent pituitary adenoma","volume":"150","author":"Romeike","year":"2008","journal-title":"Acta Neurochir"},{"issue":"6","key":"2023112320450283800_luad097-B9","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1440-1789.2012.01314.x","article-title":"T-cell lymphoblastic lymphoma\/leukemia presenting as a pituitary mass lesion: a case report and review of the literature","volume":"32","author":"Wiens","year":"2012","journal-title":"Neuropathology"},{"issue":"4","key":"2023112320450283800_luad097-B10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/neup.12375","article-title":"T cell lymphoblastic lymphoma\/leukemia within an adrenocorticotropic hormone and thyroid stimulating hormone positive pituitary adenoma: a cytohistological correlation emphasizing importance of intra-operative squash smear","volume":"37","author":"Gupta","year":"2017","journal-title":"Neuropathology"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/5\/luad097\/53705681\/luad097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/5\/luad097\/53705681\/luad097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T20:45:23Z","timestamp":1700772323000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad097\/7257927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad097","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,9,1]]},"article-number":"luad097"}}