{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:30:19Z","timestamp":1757781019284,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pheochromocytoma is a tumor of chromaffin cells causing catecholamines overproduction. Interleukin-6 (IL-6), a cytokine, is central to inflammation and immunity. Few studies have reported IL-6\u2013producing pheochromocytoma whose underlying mechanism has not been elucidated. Herein, we present a case of pheochromocytoma whose clinical manifestations changed, and IL-6 levels elevated over time. A 48-year-old woman was referred to our hospital for fever and hepatic dysfunction. Six years prior, a right adrenal tumor was detected during the examination for ovarian teratoma without C-reactive protein (CRP) elevation. Several imaging studies at our hospital showed no abnormalities except for an increase in the size of the adrenal tumor and hepatomegaly. In addition, antibiotics did not improve the fever. Laboratory tests showed elevated levels of CRP with IL-6 elevation. An enlarged adrenal tumor was detected. Administering doxazosin lowered the CRP and IL-6 levels, then IL-6\u2013producing pheochromocytoma was suspected, and adrenalectomy was performed. After surgery, fever and hepatic function were improved, and the CRP and IL-6 levels were normalized. Immunostaining of the resected tissue showed IL-6 focal positivity, which meant the phenotype of tumor cells focally changed their phenotypes over time. IL-6\u2013producing pheochromocytoma should be considered in patients with adrenal tumors and fever of unknown origin.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad106","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T08:36:05Z","timestamp":1693643765000},"source":"Crossref","is-referenced-by-count":3,"title":["Acquisition of Interleukin-6 Production Ability Over Time With Pheochromocytoma"],"prefix":"10.1210","volume":"1","author":[{"given":"Yohei","family":"Toyoda","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Keiju Medical Centre , Nanao, Ishikawa 926-8605 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Aiga","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Medicine of Future, Kanazawa University Graduate School of Medicine , Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-3018","authenticated-orcid":false,"given":"Mitsuhiro","family":"Kometani","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Medicine of Future, Kanazawa University Graduate School of Medicine , Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-158X","authenticated-orcid":false,"given":"Takashi","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Medicine of Future, Kanazawa University Graduate School of Medicine , Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"issue":"6","key":"2023102813284050200_luad106-B1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/MPA.0b013e3181ebb4f0","article-title":"The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer","volume":"39","author":"Chen","year":"2010","journal-title":"Pancreas"},{"issue":"10","key":"2023102813284050200_luad106-B2","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1007\/s40618-021-01532-5","article-title":"Interleukin-6 producing pheochromocytoma\/paraganglioma: case series from a tertiary referral centre for pheochromocytomas and paragangliomas","volume":"44","author":"Meijs","year":"2021","journal-title":"J Endocrinol 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study","volume":"24","author":"Cheng","year":"2018","journal-title":"Endocr Pract"},{"issue":"3","key":"2023102813284050200_luad106-B6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/1947601910366719","article-title":"The von Hippel-Lindau tumor suppressor protein is destabilized by Src: implications for tumor angiogenesis and progression","volume":"1","author":"Chou","year":"2010","journal-title":"Genes Cancer"},{"issue":"1","key":"2023102813284050200_luad106-B7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.smim.2014.01.008","article-title":"The two faces of IL-6 in the tumor microenvironment","volume":"26","author":"Fisher","year":"2014","journal-title":"Semin Immunol"},{"issue":"4","key":"2023102813284050200_luad106-B8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2009.10.014","article-title":"An epigenetic switch involving NF-\u03baB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation","volume":"139","author":"Iliopoulos","year":"2009","journal-title":"Cell"},{"key":"2023102813284050200_luad106-B9","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.587779","article-title":"Histopathological analysis of tumor microenvironment and angiogenesis in pheochromocytoma","volume":"11","author":"Gao","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2023102813284050200_luad106-B10","article-title":"Asymptomatic and biochemically silent pheochromocytoma with characteristic findings on imaging","volume":"2020","author":"Spiro","year":"2020","journal-title":"Case Rep Endocrinol"}],"container-title":["JCEM Case 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