{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:13Z","timestamp":1753883533937,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A single parathyroid adenoma is the most common cause of primary hyperparathyroidism (PHPT). However, multiple synchronous adenomas can be found at surgery. More uncommon are ipsilateral synchronous adenomas, and that combined with a supernumerary gland, is even more rare. Here we present a case of PHPT due to an ipsilateral double adenoma of the inferior parathyroid gland, which was supernumerary. The diagnosis was made preoperatively by ultrasonography; however, sestamibi scan showed only a single hyperfunctioning gland on the left side. This was further substantiated by the use of intraoperative parathyroid hormone (PTH) monitoring, wherein PTH levels decreased to less than 50% of preoperative values only after the complete removal of the second adenomatous gland. This case report highlights the importance of preoperative localization and intraoperative PTH monitoring in evaluating patients with PHPT in the setting of multiple synchronous parathyroid adenoma.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad113","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T17:23:18Z","timestamp":1695403398000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary Adenoma Arising From Two Ipsilateral Supernumerary Inferior Parathyroid Adenomas"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-5373","authenticated-orcid":false,"given":"Marine","family":"Bolliet","sequence":"first","affiliation":[{"name":"Department of Surgery, Ascension Providence Hospital-Michigan State University College of Human Medicine, Southfield Campus , Southfield, MI 48075 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9320-9414","authenticated-orcid":false,"given":"Binit","family":"Katuwal","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ascension Providence Hospital-Michigan State University College of Human Medicine, Southfield Campus , Southfield, MI 48075 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandra","family":"Kolachalam","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ascension Providence Hospital-Michigan State University College of Human Medicine, Southfield Campus , Southfield, MI 48075 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"issue":"6","key":"2023102813280723900_luad113-B1","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.surg.2013.06.051","article-title":"The prevalence of undiagnosed and unrecognized primary hyperparathyroidism: a population-based analysis from the electronic medical record","volume":"154","author":"Press","year":"2013","journal-title":"Surgery"},{"issue":"10","key":"2023102813280723900_luad113-B2","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1007\/s002689900524","article-title":"Surgical significance of supernumerary parathyroid glands in renal hyperparathyroidism","volume":"22","author":"Numano","year":"1998","journal-title":"World J Surg"},{"issue":"8","key":"2023102813280723900_luad113-B3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00423-015-1348-1","article-title":"Sporadic multiple parathyroid gland disease\u2014a consensus report of the European society of endocrine surgeons (ESES)","volume":"400","author":"Barczy\u0144ski","year":"2015","journal-title":"Langenbeck's Arch 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parathyroidectomy","volume":"257","author":"Mazeh","year":"2013","journal-title":"Ann Surg"},{"issue":"3","key":"2023102813280723900_luad113-B7","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00268-013-2327-8","article-title":"Cure predictability during parathyroidectomy","volume":"38","author":"Udelsman","year":"2014","journal-title":"World J Surg"},{"issue":"6","key":"2023102813280723900_luad113-B8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.surg.2003.07.009","article-title":"Double adenomas revisited: nonuniform distribution favors enlarged superior parathyroids (fourth pouch disease)","volume":"134","author":"Milas","year":"2003","journal-title":"Surgery"},{"issue":"6","key":"2023102813280723900_luad113-B9","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1097\/01.MLG.0000163745.57542.FE","article-title":"Existence and anatomic distribution of double parathyroid adenoma","volume":"115","author":"Abboud","year":"2005","journal-title":"Laryngoscope"},{"issue":"7","key":"2023102813280723900_luad113-B10","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1136\/jcp.31.7.626","article-title":"A histological comparison of adenomatous and hyperplastic parathyroid glands","volume":"31","author":"Lawrence","year":"1978","journal-title":"J Clin Pathol"}],"container-title":["JCEM Case 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