{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:42Z","timestamp":1753883622827,"version":"3.41.2"},"reference-count":8,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Crooke cell adenoma (CCA) is a rare and aggressive subtype of a corticotroph adenoma, which requires lifetime surveillance. There have been 106 cases of CCAs reported in the English literature. We describe 2 cases of CCA, a 48-year-old man and an 84-year-old woman who both presented with binocular diplopia and temple pain. Neither case had clinical Cushing syndrome. Laboratory values for the 48-year-old man revealed, adrenocorticotropin (ACTH) 103\u2005pg\/mL (22\u2005pmol\/L) (RR: 7-63\u2005pg\/mL) and evening cortisol 14\u2005\u00b5g\/dL (386\u2005nmol\/L) (RR: 2.7-10.5\u2005\u00b5g\/dL). Computed tomography imaging demonstrated a mass adjacent to the right cavernous sinus extending into the sphenoid sinus. He underwent tumor resection with adjuvant radiation and has had a stable residual tumor for 4 years. Preoperative laboratory values for the 84-year-old woman revealed, ACTH 69\u2005pg\/mL (15 pmol\/L) (RR: 7-63\u2005pg\/mL) and evening cortisol 16.2\u2005\u00b5g\/dL (447\u2005nmol\/L) (RR: 2.7-10.5 \u00b5g\/dL). Brain magnetic resonance imaging revealed, a mass compressing the optic chiasm. She underwent resection and has had a stable residual tumor for 2 years. Surgical pathology in both cases revealed cytoplasmic hyaline deposits of more than 50% of the tumor cells, consistent with CCA. The CCA although rare, should be considered when evaluating cases with subclinical Cushing disease and visual symptoms.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad114","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T11:03:14Z","timestamp":1700132594000},"source":"Crossref","is-referenced-by-count":1,"title":["Pituitary Crooke Cell Adenoma: Two Cases of an Aggressive Pituitary Adenoma"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-3659","authenticated-orcid":false,"given":"Adeyinka","family":"Taiwo","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, University of Iowa Health Care , Iowa City, IA 52246 , USA"},{"name":"Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, IA 52246 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7106-7286","authenticated-orcid":false,"given":"Vijayvardhan","family":"Kamalumpundi","sequence":"additional","affiliation":[{"name":"Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, IA 52246 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2904-0909","authenticated-orcid":false,"given":"Nicole","family":"Becker","sequence":"additional","affiliation":[{"name":"Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, IA 52246 , USA"},{"name":"Department of Pathology, University of Iowa Health Care , Iowa City, IA 52246 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-6234","authenticated-orcid":false,"given":"Marcelo","family":"Correia","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, University of Iowa Health Care , Iowa City, IA 52246 , USA"},{"name":"Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, IA 52246 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"issue":"1","key":"2023121603031475900_luad114-B1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","article-title":"Overview of the 2022 WHO classification of pituitary tumors","volume":"33","author":"Asa","year":"2022","journal-title":"Endocr Pathol"},{"issue":"5","key":"2023121603031475900_luad114-B2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1227\/NEU.0000000000000657","article-title":"Crooke's cell tumors of the pituitary","volume":"76","author":"Di Ieva","year":"2015","journal-title":"Neurosurgery"},{"key":"2023121603031475900_luad114-B3","doi-asserted-by":"crossref","first-page":"947085","DOI":"10.3389\/fendo.2022.947085","article-title":"Prevalence and clinical characteristics of Crooke's cell adenomas in 101 patients with T-PIT-positive pituitary adenomas: case series and literature review","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"2023121603031475900_luad114-B4","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1097\/00000478-200310000-00005","article-title":"Crooke's cell adenoma of the pituitary: an aggressive variant of corticotroph adenoma","volume":"27","author":"George","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"2023121603031475900_luad114-B5","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1016\/j.wneu.2021.11.049","article-title":"Functioning Crooke cell adenomas: case series and literature review","volume":"158","author":"Giraldi","year":"2022","journal-title":"World Neurosurg"},{"key":"2023121603031475900_luad114-B6","doi-asserted-by":"crossref","first-page":"e898","DOI":"10.1016\/j.wneu.2020.03.152","article-title":"Gamma knife radiosurgery in patients with crooke cell adenoma","volume":"138","author":"Snyder","year":"2020","journal-title":"World Neurosurg"},{"key":"2023121603031475900_luad114-B7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jns.2016.11.024","article-title":"Safety and efficacy of fractionated stereotactic radiotherapy and stereotactic radiosurgery for treatment of pituitary adenomas: A systematic review and meta-analysis","volume":"372","author":"Li","year":"2017","journal-title":"J Neurol Sci"},{"issue":"2","key":"2023121603031475900_luad114-B8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.nec.2015.11.006","article-title":"The contemporary role of stereotactic radiosurgery in the treatment of meningiomas","volume":"27","author":"Cohen-Inbar","year":"2016","journal-title":"Neurosurg Clin N Am"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/6\/luad114\/54078594\/luad114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/6\/luad114\/54078594\/luad114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T03:04:39Z","timestamp":1702695879000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad114\/7424363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11,3]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad114","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,11]]},"article-number":"luad114"}}