{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:35:26Z","timestamp":1773030926967,"version":"3.50.1"},"reference-count":10,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hyperthyroidism due to gestational trophoblastic disease (GTD) is a rare but potentially life-threatening condition. Optimal perioperative management is crucial for favorable outcomes and prevention of thyroid storm. However, scarce data exist defining the ideal approach to this complex clinical presentation. This case report describes a first-time pregnant 32-year-old woman who was found to be biochemically hyperthyroid in the context of a 10-week gestation molar pregnancy. Despite her biochemical values, the patient remained clinically asymptomatic of her thyroid disease. The Gynecology and Anesthesiology services urgently consulted Endocrinology, and empiric treatment for prevention of potential impending thyroid storm was initiated prior to operative uterine evacuation. After 2 uneventful dilation and curettages with chemotherapy and a transient prescription of antithyroid medication, the patient normalized her human chorionic gonadotropin (hCG) level and recovered to biochemical euthyroidism. Other than a pruritic rash that may have been due to propylthiouracil, the patient's hyperthyroidism improved without further complications. This case highlights the importance of recognizing the link between GTD and thyrotoxicosis to allow for timely initiation of appropriate preoperative treatment. Fortunately, the multidisciplinary approach facilitated management to prevent evolution to thyroid storm.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad129","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T05:37:29Z","timestamp":1701927449000},"source":"Crossref","is-referenced-by-count":4,"title":["Molar Pregnancy\u2013Induced Hyperthyroidism: The Importance of Early Recognition and Timely Preoperative Management"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-1555","authenticated-orcid":false,"given":"Laurel","family":"Walfish","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, McGill University , Montreal, Quebec H4A 3J1 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-1171","authenticated-orcid":false,"given":"Nisha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, McGill University , Montreal, Quebec H4A 3J1 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-5548","authenticated-orcid":false,"given":"Dong Bach","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, McGill University Health Center , Montreal, Quebec H4A 3J1 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-8744","authenticated-orcid":false,"given":"Mark","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, McGill University Health Centre , Montreal, Quebec H4A 3J1 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"issue":"11","key":"2023121603040575500_luad129-B1","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.6004\/jnccn.2019.0053","article-title":"Gestational trophoblastic neoplasia, version 2.2019, NCCN clinical practice guidelines in oncology","volume":"17","author":"Abu-Rustum","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"issue":"3","key":"2023121603040575500_luad129-B2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41574-021-00604-z","article-title":"Assessment and treatment of thyroid disorders in pregnancy and the postpartum period","volume":"18","author":"Lee","year":"2022","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"2023121603040575500_luad129-B3","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/0002-9378(76)90518-4","article-title":"Serum human chorionic gonadotropin levels throughout normal pregnancy","volume":"126","author":"Braunstein","year":"1976","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"2023121603040575500_luad129-B4","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/bjc.2011.139","article-title":"Hyperthyroidism and human chorionic gonadotrophin production in gestational trophoblastic disease","volume":"104","author":"Walkington","year":"2011","journal-title":"Br J Cancer"},{"issue":"4","key":"2023121603040575500_luad129-B5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5811\/cpcem.2019.9.43656","article-title":"Gestational trophoblastic disease-induced thyroid storm","volume":"3","author":"Blick","year":"2019","journal-title":"Clin Pract Cases Emerg Med"},{"key":"2023121603040575500_luad129-B6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"2017 Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum","volume":"27","author":"Alexander","year":"2017","journal-title":"Thyroid"},{"issue":"10","key":"2023121603040575500_luad129-B7","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"ATA Hyperthyroidism management guidelines","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"issue":"1","key":"2023121603040575500_luad129-B8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.anclin.2019.10.006","article-title":"Anesthesia for endocrine emergencies","volume":"38","author":"Peramunage","year":"2020","journal-title":"Anesthesiol Clin"},{"issue":"7","key":"2023121603040575500_luad129-B9","doi-asserted-by":"crossref","first-page":"e242131","DOI":"10.1136\/bcr-2021-242131","article-title":"Thyrotoxicosis: a rare presentation of molar pregnancy","volume":"14","author":"De Guzman","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2023121603040575500_luad129-B10","first-page":"104487","article-title":"Perioperative management of the thyrotoxic patients: A systematic review","volume":"81","author":"Terefe","year":"2022","journal-title":"Ann Med Sur"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/6\/luad129\/54078578\/luad129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/1\/6\/luad129\/54078578\/luad129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T03:04:22Z","timestamp":1702695862000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad129\/7459472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11,3]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad129","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,11]]},"article-number":"luad129"}}