{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:22Z","timestamp":1753883602532,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>All girls presenting with virilization (which signifies severe hyperandrogenism) warrant thorough investigation. Ovarian hyperthecosis (OHT) is a rare cause of virilization in premenopausal women. Here, we report the case of a previously healthy 12-year-old Chinese girl with signs of virilization at puberty. Her serum total testosterone was elevated at 5.1\u2005nmol\/L (146.97\u2005ng\/dL) (normal: &amp;lt;1.4\u2005nmol\/L, &amp;lt;40.35\u2005ng\/dL). Workup for Cushing syndrome, sex development disorders, congenital adrenal hyperplasia, and adrenal and ovarian androgen-secreting tumors was unrevealing. Ovarian and adrenal venous sampling demonstrated ovarian hyperandrogenism without lateralization. Ovarian biopsy revealed nests of theca cells in the stroma of the right ovary, substantiating the diagnosis of OHT. A single dose of a GnRH analog resulted in the complete suppression of serum testosterone, supporting the diagnosis of OHT. Medical treatment with hormonal replacement therapy normalized serum testosterone levels. Our case report illustrates the diagnostic approach to virilization among girls at puberty and the diagnosis of OHT as the underlying pathology.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad140","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T05:52:49Z","timestamp":1702705969000},"source":"Crossref","is-referenced-by-count":2,"title":["Ovarian Hyperthecosis in a 12-year-old Chinese Girl Presenting With Virilization"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-9454","authenticated-orcid":false,"given":"Tiffany Sin-ting","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, United Christian Hospital , 999077 , Hong Kong"},{"name":"Department of Pediatrics and Adolescent Medicine, Tuen Mun Hospital , 999077 , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice Wai-yu","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Tuen Mun Hospital , 999077 , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoi-fung","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tuen Mun Hospital , 999077 , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lap-ming","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Tuen Mun Hospital , 999077 , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"issue":"5","key":"2024010813091563600_luad140-B1","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1210\/clinem\/dgaa948","article-title":"Approach to the virilizing girl at puberty","volume":"106","author":"Santi","year":"2021","journal-title":"J 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women?","volume":"59","author":"Kaltsas","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"2024010813091563600_luad140-B8","doi-asserted-by":"crossref","first-page":"e232783","DOI":"10.1136\/bcr-2019-232783","article-title":"Severe hyperandrogenism due to ovarian hyperthecosis in a young woman","volume":"12","author":"Goyal","year":"2019","journal-title":"BMJ Case Rep"},{"issue":"1","key":"2024010813091563600_luad140-B9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0015-0282(00)01645-9","article-title":"Long-term remission of ovarian hyperandrogenism after short-term treatment with a gonadotropin-releasing hormone agonist","volume":"75","author":"Efstathiadou","year":"2001","journal-title":"Fertil Steril"},{"issue":"1","key":"2024010813091563600_luad140-B10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/cen.13492","article-title":"Clinical case seminar: postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis","volume":"88","author":"Mamoojee","year":"2018","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["JCEM Case 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