{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:18:27Z","timestamp":1790968707907,"version":"4.1.0"},"reference-count":10,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We report a case of a 55-year-old postmenopausal woman who presented with symptoms of fatigue, male pattern hair loss, and hirsutism over 3 years. Investigations showed elevated total testosterone levels of 5.0\u2005nmol\/L (1.44\u2005ng\/mL; range, 0.3-3.1\u2005nmol\/L) using Beckman-Unicel-DXI-800 immunoassay. Testosterone levels were repeated by liquid chromatography-tandem mass spectrometry and were found to be elevated at 7.3\u2005nmol\/L (2.10\u2005ng\/mL). Estradiol was detectable and free androgen index was elevated. Dehydroepiandrosterone sulfate levels and androstenedione were within normal range, suggesting a nonadrenal source. Computed tomography scan of the abdomen showed no evidence of adrenal or adnexal tumor. GnRH analog stimulation test led to reduction of gonadotrophins and normalization of testosterone within 4 weeks. She had a biopsy of a cranial hair follicle, which showed androgenic alopecia. These investigations confirmed an ovarian source of androgens. Subsequently, she underwent bilateral salpingo-oophorectomy. Histological study of gonadal tissue confirmed the diagnosis of ovarian hyperthecosis. Four weeks after oophorectomy, her testosterone levels normalized and clinical symptoms improved. Ovarian hyperthecosis is a rare cause of hyperandrogenism in postmenopausal women and can pose a diagnostic and therapeutic challenge. Careful history and physical examination along with critical analysis of biochemistry and imaging studies is crucial for correct diagnosis.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad148","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T22:50:00Z","timestamp":1701989400000},"source":"Crossref","is-referenced-by-count":2,"title":["A Case of Ovarian Hyperthecosis in a Postmenopausal Woman"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3379-9978","authenticated-orcid":false,"given":"Saira","family":"Yousaf","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Lister Hospital, East and North Hertfordshire NHS Foundation Trust, Stevenage SG1 4AB, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryizan","family":"Nizar","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Great Western Hospitals NHS Foundation Trust , Swindon SN3 6BB, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"John","sequence":"additional","affiliation":[{"name":"Department of Pathology, Great Western Hospitals NHS Foundation Trust , Swindon SN3 6BB, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Great Western Hospitals NHS Foundation Trust , Swindon SN3 6BB, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"issue":"5 Pt 2","key":"2023120722450442100_luad148-B1","first-page":"893","article-title":"Postmenopausal hyperthecosis: functional dysregulation of androgenesis in climacteric ovary","volume":"99","author":"Krug","year":"2002","journal-title":"Obstet 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