{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T17:38:36Z","timestamp":1769881116455,"version":"3.49.0"},"reference-count":10,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32DK007217"],"award-info":[{"award-number":["T32DK007217"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01DK136965"],"award-info":[{"award-number":["U01DK136965"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK101530"],"award-info":[{"award-number":["R01DK101530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK119955"],"award-info":[{"award-number":["R01DK119955"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pheochromocytomas are intra-adrenal sympathetic neuroendocrine tumors that arise from chromaffin cells. Paragangliomas similarly arise from chromaffin cells, although at extra-adrenal sites such as sympathetic paraganglia in the abdomen\/thorax, or parasympathetic paraganglia in the head\/neck. Collectively, pheochromocytomas and paragangliomas are important to diagnose and resect because they may secrete harmful levels of catecholamines, have mass effects, hemorrhage, and\/or metastasize. Anatomic imaging of pheochromocytomas is usually completed with computed tomography or magnetic resonance imaging; however, functional imaging may be used to provide additional localization, staging, and\/or biologic information. Accordingly, selection of the proper functional imaging modality can be critical to developing the optimal therapeutic strategy. 68Gallium- and 64Copper-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-octreotate positron emission tomography computed tomography (68Ga- and 64Cu-DOTATATE) are widely used in evaluating pheochromocytomas and paragangliomas, although data regarding the sensitivity for diagnosing pheochromocytoma are limited. We report 2 cases of pheochromocytoma that showed nondiagnostic 68Ga-DOTATATE uptake but were subsequently visualized using alternative functional imaging modalities. Additionally, we provide a review of the literature to highlight the underappreciated limitations of functional adrenal imaging with somatostatin-based compounds.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad149","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T11:39:58Z","timestamp":1701430798000},"source":"Crossref","is-referenced-by-count":3,"title":["Caution on the Use of 68Ga-DOTATATE for the Diagnosis of Pheochromocytoma: A Report of 2 Cases"],"prefix":"10.1210","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5637-5591","authenticated-orcid":false,"given":"Leor","family":"Needleman","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Stanford University , Stanford, CA 94305 , USA {C}%3C!%2D%2D%7C%7CrmComment%7C%7C%3C~show%20%5BAQ%20ID%3DAQ3%5D~%3E%2D%2D%3E"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Enamandram","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stanford University , Stanford, CA 94305 , USA {C}%3C!%2D%2D%7C%7CrmComment%7C%7C%3C~show%20%5BAQ%20ID%3DAQ4%5D~%3E%2D%2D%3E"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-3589","authenticated-orcid":false,"given":"Justin P","family":"Annes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Stanford University , Stanford, CA 94305 , USA {C}%3C!%2D%2D%7C%7CrmComment%7C%7C%3C~show%20%5BAQ%20ID%3DAQ3%5D~%3E%2D%2D%3E"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"issue":"1","key":"2023121603040520800_luad149-B1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40644-016-0084-2","article-title":"68Ga-DOTATATE and 18F-FDG PET\/CT in paraganglioma and pheochromocytoma: utility, patterns and heterogeneity","volume":"16","author":"Chang","year":"2016","journal-title":"Cancer Imaging"},{"issue":"7","key":"2023121603040520800_luad149-B2","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1007\/s00259-015-3268-2","article-title":"Prospective comparison of 68Ga-DOTATATE and 18F-FDOPA PET\/CT in patients with various pheochromocytomas and paragangliomas with emphasis on sporadic cases","volume":"43","author":"Archier","year":"2016","journal-title":"Eur J Nucl Med Mol 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study","volume":"63","author":"Jha","year":"2022","journal-title":"J Nucl Med"},{"issue":"3","key":"2023121603040520800_luad149-B6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2967\/jnumed.118.211706","article-title":"Performance of 68 Ga-DOTA\u2013conjugated somatostatin receptor\u2013targeting peptide PET in detection of pheochromocytoma and paraganglioma: a systematic review and metaanalysis","volume":"60","author":"Han","year":"2019","journal-title":"J Nucl Med"},{"issue":"2","key":"2023121603040520800_luad149-B7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/cen.13737","article-title":"Role of DOTATATE-PET\/CT in preoperative assessment of phaeochromocytoma and paragangliomas","volume":"89","author":"Gild","year":"2018","journal-title":"Clin Endocrinol"},{"issue":"11","key":"2023121603040520800_luad149-B8","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1210\/jc.2003-030262","article-title":"Somatostatin receptor subtypes in human 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