{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:18:24Z","timestamp":1792631904318,"version":"4.5.0"},"reference-count":10,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Williams syndrome (WS) is a rare genetic disorder with multisystem involvement associated with hypercalcemia. The cause of this hypercalcemia is poorly understood and while primarily associated with WS children, it is also observed in adults. A 51-year-old woman with intellectual disability, renal insufficiency, recurrent pancreatitis, and intermittent hypercalcemia despite partial parathyroidectomy presented with hypercalcemia to 14\u2005mg\/dL (3.49\u2005mmol\/L; normal 8.6-10.5\u2005mg\/dL [2.12-2.62\u2005mmol\/L]) at routine follow-up. Laboratory testing was notable for acute-on-chronic renal failure with unremarkable vitamin D, urine calcium, and parathyroid hormone. She presented to the emergency department and was admitted. Treatment with bisphosphonates, calcitonin, and intravenous fluids decreased calcium to 9.4\u2005mg\/dL (2.35\u2005mmol\/L) and improved kidney function. She was discharged with recommendations for increased oral hydration, a low-calcium diet, and outpatient follow-up. Her phenotype was suspicious for WS, later confirmed with genetic testing. This case exemplifies both the increased risk of hypercalcemia in WS adults and the need to consider WS in hypercalcemic adults with intellectual disability. It also serves to illustrate the importance of recognizing WS features in potentially undiagnosed adults and reviews guidelines for hypercalcemia surveillance and management in WS adults.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad164","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T14:53:03Z","timestamp":1704207183000},"source":"Crossref","is-referenced-by-count":3,"title":["Incidental Diagnosis of Williams Syndrome in an Adult With Recurrent Hypercalcemia"],"prefix":"10.1210","volume":"2","author":[{"given":"Seth","family":"Tersteeg","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Virginia , Charlottesville, VA 22908 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimer","family":"Bakhutashvili","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Virginia , Charlottesville, VA 22908 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Crook","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Virginia , Charlottesville, VA 22908 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6321-3447","authenticated-orcid":false,"given":"Heather A","family":"Ferris","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Virginia , Charlottesville, VA 22908 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"issue":"1","key":"2024010813103889600_luad164-B1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41572-021-00276-z","article-title":"Williams syndrome","volume":"7","author":"Kozel","year":"2022","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"2024010813103889600_luad164-B2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/ajmg.c.30139","article-title":"Diagnosis and management of medical problems in adults with Williams\u2013Beuren syndrome","volume":"145C","author":"Pober","year":"2007","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"2","key":"2024010813103889600_luad164-B3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ridd.2009.12.013","article-title":"Health and social outcomes in adults with Williams syndrome: findings from cross-sectional and longitudinal cohorts","volume":"31","author":"Elison","year":"2010","journal-title":"Res Dev Disabil"},{"issue":"3","key":"2024010813103889600_luad164-B4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/ajmg.a.30400","article-title":"Multisystem study of 20 older adults with Williams syndrome","volume":"131","author":"Cherniske","year":"2004","journal-title":"Am J Med Genet A"},{"issue":"1","key":"2024010813103889600_luad164-B5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/MED.0000000000000588","article-title":"Growth, body composition, and endocrine issues in Williams syndrome","volume":"28","author":"Stanley","year":"2021","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"16","key":"2024010813103889600_luad164-B6","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jama.2022.18331","article-title":"Hypercalcemia: a review","volume":"328","author":"Walker","year":"2022","journal-title":"JAMA"},{"issue":"3","key":"2024010813103889600_luad164-B7","doi-asserted-by":"crossref","first-page":"e213","DOI":"10.4158\/EP161384.CR","article-title":"Williams-Beuren syndrome with primary hyperparathyroidism: a rare diagnosis in a rare genetic syndrome","volume":"3","author":"Goswami","year":"2017","journal-title":"AACE Clin Case Rep"},{"key":"2024010813103889600_luad164-B8","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jpeds.2016.08.027","article-title":"Hypercalcemia in patients with Williams-Beuren syndrome","volume":"178","author":"Sindhar","year":"2016","journal-title":"J Pediatr"},{"issue":"6","key":"2024010813103889600_luad164-B9","doi-asserted-by":"crossref","first-page":"e1626","DOI":"10.1542\/peds.2011-2507","article-title":"Williams-Beuren syndrome hypercalcemia: is TRPC3 a novel mediator in calcium homeostasis?","volume":"129","author":"Letavernier","year":"2012","journal-title":"Pediatrics"},{"issue":"1","key":"2024010813103889600_luad164-B10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1139\/O10-114","article-title":"WSTF does it all: a multifunctional protein in transcription, repair, and replication","volume":"89","author":"Barnett","year":"2011","journal-title":"Biochem Cell Biol"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/1\/luad164\/55115045\/luad164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/1\/luad164\/55115045\/luad164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T13:47:01Z","timestamp":1704721621000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad164\/7504966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,15]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad164","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2023,12,15]]},"article-number":"luad164"}}