{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:14:02Z","timestamp":1791645242905,"version":"4.3.4"},"reference-count":10,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Long-acting glucagon-like peptide-1 receptor agonists have traditionally been used for glycemic control in type 2 diabetes mellitus. More recently, the medical community in the United States has used its most common side effect, weight loss, as an adjunct therapy for weight management in certain populations. Little is known about the effects of semaglutide in pregnancy. But in nonpregnant people, nausea, vomiting, decreased appetite, and abdominal cramping are common side effects. Here we present the first reported case of hyperemesis gravidarum (HG) induced by semaglutide. Our patient presented at 7 weeks\u2019 gestational age with 4 days of extreme nausea, vomiting, abdominal cramping, and anorexia, symptoms that she did not experience in prior pregnancies. The patient was treated with little symptomatic improvement during her hospitalization. She later informed the medical team of her use of a high dose of subcutaneous semaglutide (2 mg) the day of symptom onset before discovering her pregnancy; semaglutide was obtained online without clinicians\u2019 guidance. Her symptoms resolved 6 days after taking semaglutide, which closely coincides with semaglutide's half-life. This leads us to believe that semaglutide exaggerated the physiological nausea and vomiting of pregnancy causing HG.<\/jats:p>","DOI":"10.1210\/jcemcr\/luad167","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T23:00:50Z","timestamp":1705705250000},"source":"Crossref","is-referenced-by-count":9,"title":["Semaglutide-induced Hyperemesis Gravidarum"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8605-9012","authenticated-orcid":false,"given":"Ijeoma Gloria","family":"Okeke","sequence":"first","affiliation":[{"name":"Department of Medicine, Jersey Shore University Medical Center , Neptune, NJ 07753 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Rose","family":"Camarda","sequence":"additional","affiliation":[{"name":"St.George\u2019s University School of Medicine , Grenada, West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Okeke","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jersey Shore University Medical Center , Neptune, NJ 07753 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Chaughtai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jersey Shore University Medical Center , Neptune, NJ 07753 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"2024022316555667000_luad167-B1","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.2147\/DDDT.S365416","article-title":"Clinical insight on semaglutide for chronic weight management in adults: patient selection and special considerations","volume":"16","author":"Chao","year":"2022","journal-title":"Drug Des Devel Ther"},{"key":"2024022316555667000_luad167-B2","article-title":"Glucagon-like peptide-1 receptor agonists. NCBI Bookshelf","author":"Collins"},{"key":"2024022316555667000_luad167-B3","article-title":"Hyperemesis Gravidarum. NCBI Bookshelf","author":"Jennings"},{"issue":"6","key":"2024022316555667000_luad167-B4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ajog.2021.03.006","article-title":"Hyperemesis gravidarum is associated with increased rates of termination of pregnancy and suicidal ideation: results from a survey completed by &gt;5000 participants","volume":"224","author":"Nana","year":"2021","journal-title":"Am J Obstetrics Gynecol"},{"issue":"189","key":"2024022316555667000_luad167-B5","first-page":"15","article-title":"Nausea and vomiting of pregnancy","volume":"131","author":"The American College of Obstetricians and Gynecologists","year":"2018","journal-title":"ACOG Pract Bull"},{"issue":"1","key":"2024022316555667000_luad167-B6","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41467-018-03258-0","article-title":"Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum","volume":"9","author":"Fejzo","year":"2018","journal-title":"Nat Commun"},{"key":"2024022316555667000_luad167-B7","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.2337\/dc23-S009","article-title":"9. Pharmacologic approaches to glycemic treatment: standards of care in diabetes\u20142023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"issue":"9","key":"2024022316555667000_luad167-B8","doi-asserted-by":"crossref","first-page":"e2231982","DOI":"10.1001\/jamanetworkopen.2022.31982","article-title":"Weight loss outcomes associated with SEMAGLUTIDE treatment for patients with overweight or obesity","volume":"5","author":"Ghusn","year":"2022","journal-title":"JAMA Network Open"},{"key":"2024022316555667000_luad167-B9","first-page":"1","author":"Novo Nordisk Inc","year":"2022"},{"key":"2024022316555667000_luad167-B10","article-title":"FDA approves new drug treatment for chronic weight management, first since 2014. FDA NEWS RELEASE"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/2\/luad167\/56747965\/luad167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/2\/luad167\/56747965\/luad167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T16:56:05Z","timestamp":1708707365000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luad167\/7577316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,8]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,8]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luad167","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,1,8]]},"article-number":"luad167"}}