{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:37:51Z","timestamp":1763552271568,"version":"3.41.2"},"reference-count":11,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acquired generalized lipodystrophy (AGL) is a rare condition characterized by the diffuse loss of adipose tissue resulting in hyperglycemia, severe insulin resistance, and sequelae of metabolic disease. Here, we report the case of a 32-year-old woman who developed uncontrolled hyperglycemia and significant weight loss within 2 months postpartum. Upon endocrine evaluation, she was found to have generalized loss of adiposity, hypoleptinemia, and persistent hyperglycemia despite aggressive insulin administration. Glycemic response was obtained with U-500 intramuscular insulin, pioglitazone, and metformin-sitagliptin. At 14 months postpartum, the patient achieved spontaneous remission with normoglycemia off medication and restoration of adipose tissue deposition. Autoimmune workup revealed positive antinuclear antibodies (ANA) and anti-U1-ribonucleoprotein (anti-U1-RNP) titers, suggestive of an autoimmune etiology to her condition. This case of AGL represents the first reported case of spontaneous remission and the first to develop in the postpartum period.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae009","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T18:03:37Z","timestamp":1706897017000},"source":"Crossref","is-referenced-by-count":3,"title":["Spontaneous Remission of Acquired Generalized Lipodystrophy Presenting in the Postpartum Period"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5226-8776","authenticated-orcid":false,"given":"Ranvir","family":"Bhatia","sequence":"first","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prathyusha","family":"Chennupathi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Overlook Medical Center, Atlantic Health System , Summit, NJ 07901 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7681-4615","authenticated-orcid":false,"given":"Elliot D","family":"Rosenstein","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Overlook Medical Center, Atlantic Health System , Summit, NJ 07901 , USA"},{"name":"Atlantic Medical Group, Atlantic Health System , Morristown, NJ 07960 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1833-8198","authenticated-orcid":false,"given":"Sonoo","family":"Advani","sequence":"additional","affiliation":[{"name":"Atlantic Medical Group, Atlantic Health System , Morristown, NJ 07960 , USA"},{"name":"Division of Endocrinology, Overlook Medical Center, Atlantic Health System , Summit, NJ 07901 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"2024022316563710400_luae009-B1","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.3389\/fimmu.2018.02142","article-title":"Autoantibodies against perilipin 1 as a cause of acquired generalized lipodystrophy","volume":"9","author":"Corvillo","year":"2018","journal-title":"Front Immunol"},{"issue":"2","key":"2024022316563710400_luae009-B2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00005792-200303000-00007","article-title":"Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature","volume":"82","author":"Misra","year":"2003","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"2024022316563710400_luae009-B3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2337\/db21-1172","article-title":"Autoantibodies to perilipin-1 define a subset 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pregnancy","volume":"11","author":"Abu-Raya","year":"2020","journal-title":"Front Immunol"},{"issue":"4","key":"2024022316563710400_luae009-B7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1055\/s-0031-1301284","article-title":"Thiazolidinedione response in familial lipodystrophy patients with LMNA mutations: a case series","volume":"44","author":"Luedtke","year":"2012","journal-title":"Horm Metab Res"},{"issue":"3","key":"2024022316563710400_luae009-B8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrendo.2010.199","article-title":"Lipodystrophy: pathophysiology and advances in treatment","volume":"7","author":"Fiorenza","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"2024022316563710400_luae009-B9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1586\/17512433.2016.1096772","article-title":"Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy","volume":"9","author":"Meehan","year":"2016","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"1","key":"2024022316563710400_luae009-B10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/cen.12980","article-title":"Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy","volume":"85","author":"Chan","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2024022316563710400_luae009-B11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/10428194.2015.1040015","article-title":"Lymphoma in acquired generalized lipodystrophy","volume":"57","author":"Brown","year":"2016","journal-title":"Leuk Lymphoma"}],"container-title":["JCEM Case 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