{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:22:53Z","timestamp":1771654973517,"version":"3.50.1"},"reference-count":11,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thyroid storm due to gestational trophoblastic disease (GTD) with metastatic choriocarcinoma is a rare but potentially life-threatening endocrine emergency. We report on a woman with molar pregnancy and metastatic choriocarcinoma who presented with thyroid storm (Burch-Wartofsky point scale of 45) a few weeks after the evacuation of GTD. She was initially managed with intravenous hydrocortisone, oral propylthiouracil (PTU), and esmolol infusion. After stabilization in the intensive care unit, 10 cycles of chemotherapy with etoposide, methotrexate, leucovorin, dactinomycin, and cyclophosphamide (EMA-CO) were initiated for stage 4 choriocarcinoma with brain and lung metastases. She underwent a hysterectomy soon after completing chemotherapy and received an additional 3 cycles of chemotherapy after the hysterectomy. As human chorionic gonadotropin (hCG) levels normalized, thyroid function reverted to normal as well. At the last follow-up, the patient was asymptomatic, euthyroid (without antithyroid medication), had a normal hCG titer of 1.7 mIU\/mL (normal nonpregnant reference is &amp;lt;\u202f5\u2005mIU\/mL), and the lung and brain lesions had resolved entirely. Management of thyroid storm in the presence of untreated metastatic choriocarcinoma requires a high index of suspicion and a multidisciplinary team approach to prevent complications and improve survival.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae019","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T08:44:07Z","timestamp":1710233047000},"source":"Crossref","is-referenced-by-count":5,"title":["A Case of Metastatic Choriocarcinoma-Related Paraneoplastic Thyroid Storm"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4812-6444","authenticated-orcid":false,"given":"Nidhi","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, University of Florida College of Medicine-Jacksonville , Jacksonville, FL 32209 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, University of Florida College of Medicine-Jacksonville , Jacksonville, FL 32209 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Florida College of Medicine-Jacksonville , Jacksonville, FL 32209 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2904-2338","authenticated-orcid":false,"given":"Gunjan Y","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, University of Florida College of Medicine-Jacksonville , Jacksonville, FL 32209 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"issue":"1","key":"2024032207470548600_luae019-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13044-021-00092-3","article-title":"Hyperthyroidism in gestational trophoblastic disease\u2014a literature review","volume":"14","author":"Pereira","year":"2021","journal-title":"Thyroid Res"},{"issue":"4","key":"2024032207470548600_luae019-B2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5811\/cpcem.2019.9.43656","article-title":"Gestational trophoblastic disease-induced thyroid storm","volume":"3","author":"Blick","year":"2019","journal-title":"Clin Pract Cases Emerg Med"},{"issue":"3","key":"2024032207470548600_luae019-B3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1210\/edrv.18.3.0300","article-title":"The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology","volume":"18","author":"Glinoer","year":"1997","journal-title":"Endocr Rev"},{"key":"2024032207470548600_luae019-B4","article-title":"Molar pregnancy causing thyrotoxicosis in a teenage girl with type 1 diabetes Mellitus","volume":"2","author":"Kaulfers","year":"2015","journal-title":"Glob Pediatr Health"},{"issue":"10","key":"2024032207470548600_luae019-B5","first-page":"001754","article-title":"Thyroid storm associated with testicular choriocarcinoma","volume":"7","author":"Mart\u00ednez-Gallegos","year":"2020","journal-title":"Eur J Case Rep Intern Med"},{"issue":"1","key":"2024032207470548600_luae019-B6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/thy.2017.0243","article-title":"Thyroid storm: a Japanese perspective","volume":"28","author":"Akamizu","year":"2018","journal-title":"Thyroid"},{"issue":"5","key":"2024032207470548600_luae019-B7","doi-asserted-by":"crossref","first-page":"546","DOI":"10.21037\/gs.2017.07.01","article-title":"Predictive features associated with thyrotoxic storm and management","volume":"6","author":"Bacuzzi","year":"2017","journal-title":"Gland Surg"},{"issue":"9","key":"2024032207470548600_luae019-B8","doi-asserted-by":"crossref","first-page":"e242868","DOI":"10.1136\/bcr-2021-242868","article-title":"Thyroid storm as an early presentation of hCG-producing metastatic choriocarcinoma: a case report and review of the literature","volume":"14","author":"Chivukula","year":"2021","journal-title":"BMJ Case Rep"},{"issue":"1","key":"2024032207470548600_luae019-B9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jemermed.2011.05.032","article-title":"\u201cHook-like effect\u201d causes false-negative point-of-care urine pregnancy testing in emergency patients","volume":"44","author":"Griffey","year":"2013","journal-title":"J Emerg Med"},{"issue":"2","key":"2024032207470548600_luae019-B10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/AOG.0000000000004240","article-title":"Gestational trophoblastic disease: current evaluation and management","volume":"137","author":"Soper","year":"2021","journal-title":"Obstet Gynecol"},{"issue":"1","key":"2024032207470548600_luae019-B11","first-page":"42","article-title":"Choriocarcinoma presenting with thyrotoxicosis","volume":"29","author":"Sotello","year":"2016","journal-title":"Proc (Bayl Univ Med Cent)"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/3\/luae019\/57020856\/luae019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/3\/luae019\/57020856\/luae019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T10:22:37Z","timestamp":1711102957000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae019\/7626059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2,23]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae019","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,2,23]]},"article-number":"luae019"}}