{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:44:04Z","timestamp":1787244244062,"version":"build-2736575974"},"reference-count":11,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asymptomatic primary hyperparathyroidism (PHPT) is often missed in developing nations due to limited formal healthcare exposure and biochemical screening programs. Many patients are thus only diagnosed once symptomatic. We present a 32-year-old female who developed bony protrusions in her jaw during pregnancy, resulting in a stillbirth. Three months later, during a dental consultation for worsening toothache, jaw abnormalities were detected. Radiological studies revealed bilateral mandibular radiolucent lesions, and bone biopsy confirmed histological features consistent with a brown tumor. These findings raised concerns about underlying PHPT, which was confirmed with a markedly elevated parathyroid hormone level in the presence of significant hypercalcemia. Further examination revealed impaired renal function, normal urine calcium excretion, and bilateral nephrocalcinosis. Low bone mineral density was measured with dual-energy X-ray absorptiometry, and conventional radiology identified additional low-density bony lesions in keeping with brown tumors. A parathyroid MIBI confirmed the presence of a singular parathyroid adenoma. A vague but possible family history, the patient's young age, and the severe renal and skeletal involvement prompted genetic testing. A cell division cycle 73 (CDC73) pathogenic variant, in keeping with primary hyperparathyroidism jaw tumor syndrome, was identified.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae020","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T08:08:00Z","timestamp":1707725280000},"source":"Crossref","is-referenced-by-count":4,"title":["Hyperparathyroidism Jaw Tumor Syndrome, an Unforeseen Diagnosis"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8463-0705","authenticated-orcid":false,"given":"Asande","family":"Zama","sequence":"first","affiliation":[{"name":"Division of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital , Cape Town 7505 , South Africa"},{"name":"Division of Chemical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University , Cape Town 7505 , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0312-5189","authenticated-orcid":false,"given":"Elsie C","family":"Kruger","sequence":"additional","affiliation":[{"name":"Division of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital , Cape Town 7505 , South Africa"},{"name":"Division of Chemical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University , Cape Town 7505 , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7621-4679","authenticated-orcid":false,"given":"Annalise E","family":"Zemlin","sequence":"additional","affiliation":[{"name":"Division of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital , Cape Town 7505 , South Africa"},{"name":"Division of Chemical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University , Cape Town 7505 , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-4098","authenticated-orcid":false,"given":"Magda","family":"Conradie","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Stellenbosch University and Tygerberg Hospital , Cape Town 7505 , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"issue":"11","key":"2024032207472573400_luae020-B1","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1210\/jc.2018-01225","article-title":"Primary hyperparathyroidism","volume":"103","author":"Bilezikian","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"2024032207472573400_luae020-B2","doi-asserted-by":"crossref","first-page":"623667","DOI":"10.3389\/fendo.2021.623667","article-title":"Familial hyperparathyroidism","volume":"12","author":"Blau","year":"2021","journal-title":"Front 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hyperparathyroidism","volume":"58","author":"Misiorowski","year":"2017","journal-title":"Endocrine"},{"issue":"4","key":"2024032207472573400_luae020-B7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1054\/cdip.2001.0080","article-title":"Giant cell containing lesions of bone and their differential diagnosis","volume":"7","author":"Rosenberg","year":"2001","journal-title":"Curr Diag Pathol"},{"key":"2024032207472573400_luae020-B8","doi-asserted-by":"crossref","first-page":"1761030","DOI":"10.1155\/2019\/1761030","article-title":"Clinical features, treatment, and surveillance of hyperparathyroidism-jaw tumor syndrome: an up-to-date and review of the literature","volume":"2019","author":"Torresan","year":"2019","journal-title":"Int J Endocrinol"},{"issue":"11","key":"2024032207472573400_luae020-B9","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/jbmr.4665","article-title":"Epidemiology, pathophysiology, and genetics of primary hyperparathyroidism","volume":"37","author":"Minisola","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024032207472573400_luae020-B10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2265.2008.03495.x","article-title":"Hyperparathyroidism during pregnancy and the effect of rising calcium on pregnancy loss: a call for earlier intervention","volume":"71","author":"Norman","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"2024032207472573400_luae020-B11","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1002\/jbmr.4677","article-title":"Evaluation and management of primary hyperparathyroidism: summary statement and guidelines from the fifth international workshop","volume":"37","author":"Bilezikian","year":"2022","journal-title":"J Bone Miner Res"}],"container-title":["JCEM Case 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