{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:34:21Z","timestamp":1777113261735,"version":"3.51.4"},"reference-count":13,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A Sertoli-Leydig cell tumor (SLCT) is a rare ovarian tumor that often excessively secretes testosterone and its precursor, leading to virilization in females. We present a case of a female patient with persistent, severe hyperandrogenism. Our patient had a history of left oophorectomy due to an ectopic pregnancy and initially presented with amenorrhea at the age of 30. Biochemical evaluations suggested ovarian hyperandrogenism. Despite the absence of an ovarian mass, she underwent a right oophorectomy and remained hyperandrogenic postoperatively. When she established care with our endocrinology clinic at the age of 58, she had more virilizing features and total testosterone levels ranging from 10.1 to 12.0\u2005nmol\/L (292-346\u2005ng\/dL; normal reference range for women: 0.07-1.56\u2005nmol\/L; 2-45\u2005ng\/dL). While biochemical evaluations were consistent with tumorous ovarian hyperandrogenism, ultrasound and computed tomography again failed to identify the source. Finally, an 18F-fluorodeoxyglucose-positron emission tomography\/computed tomography revealed a mass in the left adnexa, and she underwent removal of the mass. The final pathology confirmed SLCT. The case highlights that SLCT may be small and slow-growing and not readily visible on conventional imaging modalities.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae025","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T16:17:21Z","timestamp":1709569041000},"source":"Crossref","is-referenced-by-count":2,"title":["The Hidden Source of Testosterone Hypersecretion in a Female\u2014A 30-Year Journey"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-3416","authenticated-orcid":false,"given":"Almira J","family":"Yang","sequence":"first","affiliation":[{"name":"Riverside University Health System Medical Center, School of Medicine, University of California, Riverside , Moreno Valley, CA 92555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iqbal","family":"Munir","sequence":"additional","affiliation":[{"name":"Riverside University Health System Medical Center, School of Medicine, University of California, Riverside , Moreno Valley, CA 92555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"2024032207470414200_luae025-B1","first-page":"3021","volume-title":"Williams Textbook of Endocrinology","author":"Auchus","year":"2020"},{"issue":"1","key":"2024032207470414200_luae025-B2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s13048-021-00909-7","article-title":"Characteristics and outcomes analysis of ovarian Sertoli-Leydig cell tumors (SLCTs): analysis of 15 patients","volume":"14","author":"Wang","year":"2021","journal-title":"J Ovarian Res"},{"issue":"1","key":"2024032207470414200_luae025-B3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4103\/0973-1482.158037","article-title":"Ovarian sertoli-leydig cell tumors: a multicenter long-term clinicopathological analysis of 27 patients","volume":"12","author":"Akman","year":"2016","journal-title":"J Cancer Res 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hyperandrogenism in a postmenopausal woman","volume":"108","author":"Hirschberg","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024032207470414200_luae025-B8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1365-2265.2003.01792.x","article-title":"Is ovarian and adrenal venous catheterization and sampling helpful in the investigation of hyperandrogenic women?","volume":"59","author":"Kaltsas","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2024032207470414200_luae025-B9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1365-2265.2008.03389.x","article-title":"Selective venous sampling for androgen-producing ovarian pathology","volume":"70","author":"Levens","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2024032207470414200_luae025-B10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1148\/rg.2021200086","article-title":"Multimodality imaging approach to 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