{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T03:21:14Z","timestamp":1771125674163,"version":"3.50.1"},"reference-count":24,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypothalamic hamartomas (HHs) are rare, benign brain tumors or lesions of the hypothalamus that are predominantly identified in cases of epilepsy and central precocious puberty (CPP), whereas isolated manifestations of infantile obesity are atypical. We herein report an 8-month-old boy with severe obesity (Kaup index 26.4 [&amp;gt;100th percentile]) and uncontrollable hyperphagia. His growth chart demonstrated remarkable weight gain that exceeded the length gain in magnitude. Brain magnetic resonance imaging identified a lesion consistent with HH. There were no episodes or clinical findings of epilepsy, CPP, or Cushing disease. Hypothalamic obesity should be considered in the diagnosis even in infants with excessive weight gain due to overeating.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae033","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T05:33:37Z","timestamp":1710826417000},"source":"Crossref","is-referenced-by-count":1,"title":["Infantile Hypothalamic Hamartoma: A Rare Presentation of Isolated Obesity"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8636-7835","authenticated-orcid":false,"given":"Mika","family":"Tsumori","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Oita University Faculty of Medicine, Yufu , Oita 879-5593 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4894-5356","authenticated-orcid":false,"given":"Tomoyo","family":"Itonaga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oita University Faculty of Medicine, Yufu , Oita 879-5593 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momoko","family":"Oyake","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oita University Faculty of Medicine, Yufu , Oita 879-5593 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9695-7004","authenticated-orcid":false,"given":"Naoki","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oita University Faculty of Medicine, Yufu , Oita 879-5593 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oita Prefectural Hospital, Oita , Oita 870-0855 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8831-1991","authenticated-orcid":false,"given":"Kenji","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oita University Faculty of Medicine, Yufu , Oita 879-5593 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"2024032207525351400_luae033-B1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pediatrneurol.2017.07.001","article-title":"Management of epilepsy due to hypothalamic hamartomas","volume":"75","author":"Khawaja","year":"2017","journal-title":"Pediatr Neurol"},{"issue":"12","key":"2024032207525351400_luae033-B2","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/dmcn.14241","article-title":"Neuropsychiatric profile of paediatric hypothalamic hamartoma: systematic review and case series","volume":"61","author":"Corbet Burcher","year":"2019","journal-title":"Dev Med Child Neurol"},{"issue":"Suppl 2(Suppl 2)","key":"2024032207525351400_luae033-B3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/epi.13756","article-title":"Hypothalamic hamartoma with epilepsy: review of endocrine comorbidity","volume":"58","author":"Harrison","year":"2017","journal-title":"Epilepsia"},{"issue":"18","key":"2024032207525351400_luae033-B4","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1212\/WNL.0000000000012773","article-title":"Hypothalamic hamartomas: evolving understanding and management","volume":"97","author":"Cohen","year":"2021","journal-title":"Neurology"},{"issue":"5","key":"2024032207525351400_luae033-B5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jpeds.2012.05.014","article-title":"Hypothalamic-pituitary lesions in pediatric patients: endocrine symptoms often precede neuro-ophthalmic presenting symptoms","volume":"161","author":"Taylor","year":"2012","journal-title":"J Pediatr"},{"issue":"8","key":"2024032207525351400_luae033-B6","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.radcr.2020.05.041","article-title":"Pre- and postnatal MR imaging of an asymptomatic giant hypothalamic hamartoma","volume":"15","author":"Cristobal","year":"2020","journal-title":"Radiol Case Rep"},{"issue":"10","key":"2024032207525351400_luae033-B7","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2176\/nmc.36.725","article-title":"Asymptomatic hypothalamic hamartoma associated with an arachnoid cyst\u2013case report","volume":"36","author":"Isaka","year":"1996","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"2024032207525351400_luae033-B8","doi-asserted-by":"crossref","first-page":"117428","DOI":"10.1016\/j.jns.2021.117428","article-title":"A systematic review of stereotactic radiofrequency ablation for hypothalamic hamartomas","volume":"424","author":"Kondajji","year":"2021","journal-title":"J Neurol Sci"},{"key":"2024032207525351400_luae033-B9","first-page":"77","volume-title":"World Health Organization, ed. 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