{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:40:36Z","timestamp":1780393236788,"version":"3.54.1"},"reference-count":22,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NUT carcinoma is an aggressive, poorly differentiated squamous cell carcinoma, defined by rearrangement of the NUTM1 (Nuclear Protein in Testis) gene. Diagnosis is challenging due to histologic similarities with other poorly differentiated tumors requiring advanced diagnostic techniques. There is no established treatment, and prognosis remains extremely poor. A 27-year-old woman without known medical history presented with a rapidly enlarging neck mass and compressive symptoms. Chemotherapy for presumed squamous cell carcinoma with a component of anaplastic thyroid cancer based on pathology was initiated. Next-generation sequencing revealed thyroid NUT carcinoma with high PD-L1 expression, prompting PD-1 targeted therapy. The patient expired shortly afterwards from progressive disease. NUT carcinoma of thyroid origin is an extremely rare disease. This case brings awareness to the disease, highlights the importance of advanced diagnostic techniques and complexities in managing patients with NUT carcinoma.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae037","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T12:12:36Z","timestamp":1711109556000},"source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of NUT Carcinoma of the Thyroid"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-0224","authenticated-orcid":false,"given":"Adam","family":"Cadesky","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism & Diabetes, Northwell , New Hyde Park, NY 11042-1069 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifka","family":"Schulman-Rosenbaum","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism & Diabetes, Northwell , New Hyde Park, NY 11042-1069 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Carter","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes & Metabolism, NYU Langone Health , Manhasset, NY 11030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism & Diabetes, Northwell , New Hyde Park, NY 11042-1069 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchie","family":"Jaggi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism & Diabetes, Northwell , New Hyde Park, NY 11042-1069 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"issue":"11","key":"2024032212122814200_luae037-B1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/pin.12727","article-title":"NUT carcinoma: clinicopathologic features, pathogenesis, and treatment","volume":"68","author":"French","year":"2018","journal-title":"Pathol Int"},{"issue":"20","key":"2024032212122814200_luae037-B2","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1158\/1078-0432.CCR-12-1153","article-title":"Clinicopathologic features and long-term outcomes of NUT midline carcinoma","volume":"18","author":"Bauer","year":"2012","journal-title":"Clin Cancer Res"},{"issue":"2","key":"2024032212122814200_luae037-B3","doi-asserted-by":"crossref","first-page":"pkz094","DOI":"10.1093\/jncics\/pkz094","article-title":"An anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: analysis of 124 patients","volume":"4","author":"Chau","year":"2019","journal-title":"JNCI Cancer Spectrum"},{"issue":"1","key":"2024032212122814200_luae037-B4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1089\/ct.2021;33.38-47","article-title":"NUT carcinoma of the thyroid: an unusual case with a complete response to treatment","volume":"33","author":"Kuo","year":"2021","journal-title":"Clin Thyroidol"},{"issue":"10","key":"2024032212122814200_luae037-B5","first-page":"1271","article-title":"Possible primary thyroid nuclear protein in testis carcinomas with NSD3::NUTM1 translocation revealed by RNA sequencing: a report of two cases","volume":"32","author":"Scherman","year":"2022","journal-title":"Thyroid"},{"issue":"2","key":"2024032212122814200_luae037-B6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12022-021-09700-2","article-title":"Thyroid carcinoma with NSD3::NUTM1 fusion: a case with thyrocyte differentiation and colloid production","volume":"33","author":"Allison","year":"2022","journal-title":"Endocr Pathol"},{"issue":"6","key":"2024032212122814200_luae037-B7","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00428-021-03103-8","article-title":"NSD3-NUTM1-rearranged carcinoma of the median neck\/thyroid bed developing after recent thyroidectomy for sclerosing mucoepidermoid carcinoma with eosinophilia: report of an extraordinary case","volume":"479","author":"Agaimy","year":"2021","journal-title":"Virchows Arch"},{"key":"2024032212122814200_luae037-B8","doi-asserted-by":"crossref","first-page":"778296","DOI":"10.3389\/fonc.2021.778296","article-title":"Primary thyroid NUT carcinoma with high PD-L1 expression and novel massive IGKV gene fusions: a case report with treatment implications and literature review","volume":"11","author":"Zhou","year":"2022","journal-title":"Front Oncol"},{"key":"2024032212122814200_luae037-B9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.mpdhp.2022.02.006","article-title":"A rare case of NUT carcinoma arising in the thyroid","volume":"28","author":"Shotton","year":"2022","journal-title":"Diagn Histopathol"},{"issue":"11","key":"2024032212122814200_luae037-B10","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3390\/ijms17111849","article-title":"The bromodomain and extra-terminal domain (BET) family: functional anatomy of BET paralogous proteins","volume":"17","author":"Taniguchi","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"8","key":"2024032212122814200_luae037-B11","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1158\/2159-8290.CD-14-0014","article-title":"NSD3\u2013NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism","volume":"4","author":"French","year":"2014","journal-title":"Cancer Discov"},{"issue":"8","key":"2024032212122814200_luae037-B12","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/s41388-020-01625-0","article-title":"Supercharging BRD4 with NUT in carcinoma","volume":"40","author":"Eagen","year":"2021","journal-title":"Oncogene"},{"key":"2024032212122814200_luae037-B13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/572951","article-title":"Cytological features of a variant NUT midline carcinoma of the lung harboring the NSD3-NUT fusion gene: a case report and literature review","volume":"2015","author":"Kuroda","year":"2015","journal-title":"Case Rep Pathol"},{"issue":"7327","key":"2024032212122814200_luae037-B14","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"issue":"21","key":"2024032212122814200_luae037-B15","first-page":"E4184","article-title":"Ectopic protein interactions within BRD4\u2013chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma","volume":"114","author":"Alekseyenko","year":"2017","journal-title":"Proc Natal Acad Sci U S A"},{"issue":"7370","key":"2024032212122814200_luae037-B16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature10509","article-title":"Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia","volume":"478","author":"Dawson","year":"2011","journal-title":"Nature"},{"issue":"13","key":"2024032212122814200_luae037-B17","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1128\/MCB.01341-10","article-title":"The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3","volume":"31","author":"Rahman","year":"2011","journal-title":"Mol Cell Biol"},{"issue":"30","key":"2024032212122814200_luae037-B18","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1200\/JCO.2018.78.2292","article-title":"Phase Ib trial with birabresib, a small-molecule inhibitor of bromodomain and extraterminal proteins, in patients with selected advanced solid tumors","volume":"36","author":"Lewin","year":"2018","journal-title":"J Clin Oncol"},{"issue":"2","key":"2024032212122814200_luae037-B19","doi-asserted-by":"crossref","first-page":"pkz093","DOI":"10.1093\/jncics\/pkz093","article-title":"Phase 1 study of molibresib (GSK525762), a bromodomain and extra-terminal domain protein inhibitor, in NUT carcinoma and other solid tumors","volume":"4","author":"Piha-Paul","year":"2019","journal-title":"JNCI Cancer Spect"},{"issue":"12","key":"2024032212122814200_luae037-B20","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/s41416-020-01077-z","article-title":"First-in-human phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours","volume":"123","author":"Ameratunga","year":"2020","journal-title":"Br J Cancer"},{"issue":"4","key":"2024032212122814200_luae037-B21","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41416-020-01180-1","article-title":"A phase 1 study of RO6870810, a novel bromodomain and extra-terminal protein inhibitor, in patients with NUT carcinoma, other solid tumours, or diffuse large B-cell lymphoma","volume":"124","author":"Shapiro","year":"2021","journal-title":"Br J Cancer"},{"issue":"12","key":"2024032212122814200_luae037-B22","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1158\/1078-0432.CCR-22-0591","article-title":"Report of the first international symposium on NUT carcinoma","volume":"28","author":"French","year":"2022","journal-title":"Clin Cancer Res"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/3\/luae037\/57059080\/luae037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/3\/luae037\/57059080\/luae037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T12:12:57Z","timestamp":1711109577000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae037\/7633503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2,23]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae037","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,2,23]]},"article-number":"luae037"}}