{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:31Z","timestamp":1753883551052,"version":"3.41.2"},"reference-count":6,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adrenal tumors with invasion into the inferior vena cava (IVC) are typically malignant. Here, we present a case of adrenocortical adenoma with protrusion into the IVC. A 70-year-old man was referred to our hospital after his magnetic resonance imaging scan of the abdomen coincidently revealed a right adrenal tumor invading the IVC. We suspected an aggressive adrenal carcinoma and tumor resection was performed. However, all 3 existing pathological criteria (Weiss, modified Weiss, and Helsinki) suggested the tumor was benign. Immunohistochemistry for CD31 showed the tumor inside the central adrenal vein (CAV), right adrenal vein (RAV), and IVC was entirely covered with CD31-positive vascular endothelial cells. The CAV is known to sometimes lack smooth muscle in its walls and normal adrenocortical cells covered by endothelial cells sometimes protrude into the CAV from this gap. These findings suggest that this tumor likely protruded into the IVC by pushing against the CAV wall, rather than by invasion into the vascular wall. In the case with adrenal tumors protruding into the IVC, the fact that the tumor surface was covered by vascular endothelial cells was considered supportive of its benign nature.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae043","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T13:57:21Z","timestamp":1713880641000},"source":"Crossref","is-referenced-by-count":0,"title":["Adrenocortical Adenoma With Protrusion Into the Inferior Vena Cava Initially Suspected to Be Adrenocortical Carcinoma"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0949-6367","authenticated-orcid":false,"given":"Hiroki","family":"Takizawa","sequence":"first","affiliation":[{"name":"Department of Metabolism & Endocrinology, Juntendo University Graduate School , Tokyo 113-8421 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reo","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Juntendo University Graduate School of Medicine , Tokyo 113-8421 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Fukumura","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Juntendo University Graduate School of Medicine , Tokyo 113-8421 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muga","family":"Terasawa","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine , Tokyo 113-8421 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Juntendo University Graduate School of Medicine , Tokyo 113-8421 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Metabolism & Endocrinology, Juntendo University Graduate School , Tokyo 113-8421 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"issue":"1","key":"2024052406514416500_luae043-B1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/003655902317259409","article-title":"Adrenal tumor with caval extension: case report and review of the literature","volume":"36","author":"Chesson","year":"2002","journal-title":"Scand J Urol Nephrol"},{"issue":"3","key":"2024052406514416500_luae043-B2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00000478-198903000-00004","article-title":"Pathologic features of prognostic significance in adrenocortical carcinoma","volume":"13","author":"Weiss","year":"1989","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"2024052406514416500_luae043-B3","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1097\/00000478-200212000-00009","article-title":"Weiss system revisited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors","volume":"26","author":"Aubert","year":"2002","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"2024052406514416500_luae043-B4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.humpath.2014.11.015","article-title":"Helsinki score-a novel model for prediction of metastases in adrenocortical carcinomas","volume":"46","author":"Pennanen","year":"2015","journal-title":"Hum Pathol"},{"key":"2024052406514416500_luae043-B5","first-page":"1225","volume-title":"Histology for Pathologists","author":"Mills","year":"2020","edition":"5th ed"},{"key":"2024052406514416500_luae043-B6","first-page":"7395050","article-title":"Was it an adrenocortical adenoma or an adrenocortical carcinoma? Limitation of the weiss scoring system in determining the malignant potential of adrenocortical tumor: report on two cases","volume":"2022","author":"Wong","year":"2022","journal-title":"Case Rep Endocrinol"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/5\/luae043\/57595493\/luae043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/5\/luae043\/57595493\/luae043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T07:39:36Z","timestamp":1716536376000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae043\/7656697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,4,23]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae043","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,4,23]]},"article-number":"luae043"}}