{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:50Z","timestamp":1753883630393,"version":"3.41.2"},"reference-count":10,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fetal thyrotoxicosis is a rare condition with high morbidity and mortality. It may complicate pregnancies in women with a history of Graves disease (GD) when transplacental passage of maternal TSH receptor antibodies stimulate the fetal thyroid gland and cause hyperthyroidism. We report the case of a 34-year-old woman with a history of GD and prior thyroidectomy, where fetal thyrotoxicosis at 21 weeks of gestation was suspected due to prenatal ultrasound findings of cardiac failure and fetal goiter. She was treated with high-dose carbimazole and followed closely by a multidisciplinary team. Her baby was delivered in good condition at 34 weeks\u2019 gestation and developed hyperthyroidism in the days after birth, which was successfully treated medically. This case highlights the importance of awareness of the condition among women with a history of GD, as well as the necessity for prompt diagnosis and treatment of this complex disease.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae060","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T08:47:18Z","timestamp":1713170838000},"source":"Crossref","is-referenced-by-count":1,"title":["Maternal Graves Disease Postthyroidectomy With Fetal Thyrotoxicosis and Goiter"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6066-8318","authenticated-orcid":false,"given":"David","family":"Fennell","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Mater Misericordiae University Hospital , Dublin , Ireland"},{"name":"Department of Endocrinology, National Maternity Hospital , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine, National Maternity Hospital , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Cathcart","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine, National Maternity Hospital , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colm P F","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Department of Neonatology, National Maternity Hospital , Dublin , Ireland"},{"name":"School of Medicine, University College Dublin , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-1226","authenticated-orcid":false,"given":"Mensud","family":"Hatunic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Mater Misericordiae University Hospital , Dublin , Ireland"},{"name":"Department of Endocrinology, National Maternity Hospital , Dublin , Ireland"},{"name":"School of Medicine, University College Dublin , Dublin , Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"issue":"1","key":"2024042306011986400_luae060-B1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40842-018-0054-7","article-title":"Graves\u2019 hyperthyroidism in pregnancy: a clinical review","volume":"4","author":"Nguyen","year":"2018","journal-title":"Clin Diabetes Endocrinol"},{"key":"2024042306011986400_luae060-B2","first-page":"100190","article-title":"Hyperthyroidism in the pregnant woman: maternal and fetal aspects","volume":"16","author":"Moleti","year":"2019","journal-title":"J Clin Transl 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thyroidectomy","volume":"50","author":"Takamura","year":"2003","journal-title":"Endocr J"},{"issue":"3","key":"2024042306011986400_luae060-B6","doi-asserted-by":"crossref","first-page":"F165","DOI":"10.1136\/fn.87.3.F165","article-title":"Neonatal thyroid disorders","volume":"87","author":"Ogilvy-Stuart","year":"2002","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2024042306011986400_luae060-B7","doi-asserted-by":"crossref","first-page":"e00081","DOI":"10.1016\/j.crwh.2018.e00081","article-title":"Fetal hyperthyroidism associated with maternal thyroid autoantibodies: a case report","volume":"20","author":"Kazakou","year":"2018","journal-title":"Case Rep Womens Health"},{"issue":"7","key":"2024042306011986400_luae060-B8","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.4103\/2230-8210.119505","article-title":"Fetal and neonatal thyrotoxicosis","volume":"17","author":"Batra","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"issue":"5","key":"2024042306011986400_luae060-B9","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/AOG.0000000000000582","article-title":"Early severe fetal graves disease in a mother after thyroid ablation and thyroidectomy","volume":"125","author":"Donnelly","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"1","key":"2024042306011986400_luae060-B10","article-title":"Fetal\/neonatal thyrotoxicosis in a newborn from a hypothyroid woman with hashimoto thyroiditis","volume":"102","author":"Kiefer","year":"2017","journal-title":"J Clin Endocrinol Metab"}],"container-title":["JCEM Case 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