{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:20Z","timestamp":1753883600530,"version":"3.41.2"},"reference-count":7,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This case report delineates the clinical presentation of a 77-year-old male who experienced falls and sustained a humerus fracture attributed to hypoglycemia. Despite the absence of insulin use and normal laboratory results for cortisol, TSH, blood count, and liver and kidney function, a fasting test revealed diminished C-peptide and insulin levels, ruling out insulinoma, exogenous insulin use, or \u03b2-cell hyperplasia. Subsequent laboratory investigations demonstrated lowered IGF-1 and elevated IGF-2 levels, indicative of an IGF-2-producing tumor as the etiology of the hypoglycemia. A positron emission tomography computed tomography scan identified a right-sided thoracic cavity tumor, prompting an open resection. Postoperatively, hypoglycemic episodes abated within 2 days, and pathology confirmed a 14.9-cm solitary fibrous tumor. Nonislet cell tumor hypoglycemia (NICTH), also known as Doege Potter syndrome, arises from aberrant production of IGF-2 or its precursors. Elevated IGF-2 levels induce hypoglycemia through heightened glucose uptake on binding to insulin receptors. The literature supports the efficacy of both surgical intervention and corticosteroids in managing NICTH. This case underscores the importance of considering NICTH as a rare etiology in unexplained hypoglycemia cases, advocating for the utility of fasting tests in diagnosis, and suggesting surgical resection as a viable treatment option when radical excision is feasible.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae061","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T17:02:01Z","timestamp":1714064521000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Falls Due to Hypoglycemia: Case of an IGF-2-producing Fibrous Tumor of the Pleura"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9958-8590","authenticated-orcid":false,"given":"Mathijs Cornelis","family":"Guijt","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Haga Ziekenhuis Den Haag , Els Borst-Eilersplein 275, 2545 AA, Den Haag , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Heineman","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cardiothoracic Surgery, Amsterdam UMC location Vrije Universiteit Amsterdam\u2014Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline Th\u00e9r\u00e8se","family":"Jonker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Alrijne Ziekenhuis Leiderdorp , Simon Smitweg 1, 2353 GA, Leiderdorp , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"issue":"6","key":"2024052407041682600_luae061-B1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1210\/er.2012-1033","article-title":"Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory, and the historical archive","volume":"34","author":"Dynkevich","year":"2013","journal-title":"Endocr 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