{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:51:11Z","timestamp":1783525871330,"version":"3.55.0"},"reference-count":9,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cribriform-morular thyroid carcinoma is a rare type of thyroid cancer. It has a strong association with familial adenomatous polyposis (FAP), a hereditary genetic disorder that predisposes individuals to the development of numerous polyps in the colon and rectum. We describe the case of a young female patient who presented with an enlarging goiter, notably without detectable thyroid nodules or masses on ultrasound, who after total thyroidectomy was found to have cribriform-morular thyroid carcinoma. This diagnosis led to genetic testing and diagnosis of FAP syndrome. We demonstrate that this rare thyroid carcinoma may present with nonsuspicious findings on sonographic evaluation while being a valuable harbinger in the diagnosis of FAP syndrome.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae062","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T15:23:00Z","timestamp":1713453780000},"source":"Crossref","is-referenced-by-count":1,"title":["A Case of Cribriform-Morular Thyroid Carcinoma Presenting Without Thyroid Nodule"],"prefix":"10.1210","volume":"2","author":[{"given":"Angela","family":"Rao","sequence":"first","affiliation":[{"name":"Division of Endocrinology, School of Medicine, Stanford University , Palo Alto, CA 94304 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5637-5591","authenticated-orcid":false,"given":"Leor","family":"Needleman","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, School of Medicine, Stanford University , Palo Alto, CA 94304 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Lauren","family":"Lalakea","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, School of Medicine, Stanford University , Palo Alto, CA 94304 , USA"},{"name":"Santa Clara Valley Medical Center , San Jose, CA 95128 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0132-5500","authenticated-orcid":false,"given":"Emory","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, School of Medicine, Stanford University , Palo Alto, CA 94304 , USA"},{"name":"Santa Clara Valley Medical Center , San Jose, CA 95128 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"issue":"1","key":"2024042306012386300_luae062-B1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12022-022-09707-3","article-title":"Overview of the 2022 WHO classification of thyroid neoplasms","volume":"33","author":"Baloch","year":"2022","journal-title":"Endocr Pathol"},{"issue":"12","key":"2024042306012386300_luae062-B2","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/dc.21309","article-title":"Cribriform-morular variant of papillary thyroid carcinoma\u2013cytological and immunocytochemical findings of 18 cases","volume":"38","author":"Hirokawa","year":"2010","journal-title":"Diagn Cytopathol"},{"issue":"3","key":"2024042306012386300_luae062-B3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12022-021-09683-0","article-title":"Cribriform-Morular thyroid carcinoma is a distinct thyroid malignancy of uncertain cytogenesis","volume":"32","author":"Boyraz","year":"2021","journal-title":"Endocr Pathol"},{"issue":"3","key":"2024042306012386300_luae062-B4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/1066896918796946","article-title":"Cribriform-Morular variant of papillary thyroid carcinoma with poorly differentiated features: a case report with immunohistochemical and molecular genetic analysis","volume":"27","author":"Corean","year":"2019","journal-title":"Int J Surg Pathol"},{"issue":"2","key":"2024042306012386300_luae062-B5","first-page":"531","article-title":"Cribriform-morular variant of papillary thyroid carcinoma at pediatric age\u2014case report and review of the literature","volume":"57","author":"Brehar","year":"2016","journal-title":"Rom J Morphol Embryol"},{"issue":"3","key":"2024042306012386300_luae062-B6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s12022-013-9274-7","article-title":"Cribriform morular variant of papillary thyroid carcinoma in a patient with an incidental neck lump: a case report and review of the literature","volume":"25","author":"Yeoh","year":"2014","journal-title":"Endocr Pathol"},{"issue":"3","key":"2024042306012386300_luae062-B7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12022-023-09775-z","article-title":"Cribriform morular thyroid carcinoma\u2014ultimobranchial pouch-related? Deep molecular insights of a unique case","volume":"34","author":"Dettmer","year":"2023","journal-title":"Endocr Pathol"},{"issue":"1","key":"2024042306012386300_luae062-B8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/thy.2011.0534","article-title":"Cribriform-morular variant of papillary thyroid carcinoma: ultrasonographic and clinical characteristics","volume":"23","author":"Chong","year":"2013","journal-title":"Thyroid"},{"issue":"8","key":"2024042306012386300_luae062-B9","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/s41379-018-0070-2","article-title":"Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT\/\u03b2-catenin pathway","volume":"31","author":"Cameselle-Teijeiro","year":"2018","journal-title":"Mod Pathol"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/4\/luae062\/57300724\/luae062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/4\/luae062\/57300724\/luae062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T06:01:41Z","timestamp":1713852101000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae062\/7649994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,3,22]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae062","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,3,22]]},"article-number":"luae062"}}