{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:52Z","timestamp":1753883572450,"version":"3.41.2"},"reference-count":15,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Parathyroid carcinoma (PC) is a rare endocrine neoplasm that typically presents with osteopenia\/osteoporosis, nephrolithiasis, asthenia, and neuropsychiatric symptoms. We describe the case of a 48-year-old woman, presenting with a large painful hematoma in the cervicomediastinal area. The neck ultrasound (US) demonstrated a solid lesion measuring 40 \u00d7 80 \u00d7 55\u2005mm, markedly hypoechoic, which extended from the right thyroid lobe to the mediastinum. The blood tests showed elevated serum calcium and parathyroid hormone (PTH) concentrations, consistent with hypercalcemic primary hyperparathyroidism. The patient was rehydrated and treated with furosemide, cholecalciferol, and bisphosphonate, and underwent right lower parathyroidectomy, right hemithyroidectomy, and lymphadenectomy of the right VI cervical level. Histological examination was diagnostic for nonangioinvasive or neuroinvasive PC, and the thyroid lobe was the site of lymphocytic thyroiditis; all removed lymph nodes were benign. The postoperative course was regular. Postoperative neck US showed a hypoechoic left thyroid lobe without evidence of residual neoplasm in the right thyroid bed. Levothyroxine therapy of 50\u2005mcg\/day was started because of serum thyrotropin concentrations elevated at 18 mcIU\/mL (normal reference range, 0.35-4.0 mIU\/mL). Eight years after diagnosis, the patient is in good general condition, with no clinical, biochemical, or imaging evidence of disease persistence\/recurrence.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae063","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T15:51:16Z","timestamp":1713455476000},"source":"Crossref","is-referenced-by-count":0,"title":["Cervicomediastinal Hematoma: Atypical Presentation of a Parathyroid Carcinoma"],"prefix":"10.1210","volume":"2","author":[{"given":"Martina","family":"Cicia","sequence":"first","affiliation":[{"name":"Unit of Endocrinology, Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Fondazione Policlinico \u201cA. Gemelli\u201d IRCCS , 00168 Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-0502","authenticated-orcid":false,"given":"Giampaolo","family":"Papi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Azienda USL Modena , 41121 Modena , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Scillitani","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo (FG) , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Corrado","sequence":"additional","affiliation":[{"name":"Pathology Unit, University of Modena and Reggio Emilia , 41125 Modena , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Locantore","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Fondazione Policlinico \u201cA. Gemelli\u201d IRCCS , 00168 Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Pontecorvi","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Fondazione Policlinico \u201cA. Gemelli\u201d IRCCS , 00168 Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"issue":"3","key":"2024042306012322200_luae063-B1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.otohns.2004.10.005","article-title":"A systematic review of the diagnosis and treatment of primary hyperparathyroidism from 1995 to 2003","volume":"132","author":"Ruda","year":"2005","journal-title":"Otolaryngol\u2013Head Neck Surg"},{"issue":"9","key":"2024042306012322200_luae063-B2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/cncr.22599","article-title":"Trends in the incidence and treatment of parathyroid cancer in the United States","volume":"109","author":"Lee","year":"2007","journal-title":"Cancer"},{"issue":"6","key":"2024042306012322200_luae063-B3","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.surg.2014.08.069","article-title":"Parathyroid carcinoma in more than 1,000 patients: a population-level analysis","volume":"156","author":"Sadler","year":"2014","journal-title":"Surgery"},{"issue":"7","key":"2024042306012322200_luae063-B4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1245\/ASO.2005.06.005","article-title":"Preoperative predictive factors for parathyroid carcinoma in patients with primary hyperparathyroidism","volume":"12","author":"Robert","year":"2005","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"2024042306012322200_luae063-B5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1530\/ERC-22-0287","article-title":"Diagnosis and management of parathyroid carcinoma: a state-of-the-art review","volume":"30","author":"Roser","year":"2023","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"2024042306012322200_luae063-B6","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/00000441-193412000-00007","article-title":"Multiple parathyroid tumors with massive mediastinal and subcutaneous hemorrhage","volume":"188","author":"Capps","year":"1934","journal-title":"Am J Med Sci"},{"key":"2024042306012322200_luae063-B7","doi-asserted-by":"crossref","first-page":"881225","DOI":"10.3389\/fendo.2022.881225","article-title":"Parathyroid carcinoma all-in-one, a rare life-threatening case with multiple systemic manifestations: case report and review of the literature","volume":"13","author":"Zelano","year":"2022","journal-title":"Front Endocrinol"},{"key":"2024042306012322200_luae063-B8","first-page":"0","article-title":"Clinical practice guideline: evaluation of the neck mass in adults","volume":"157","author":"Pynnonen","year":"2017","journal-title":"Otolaryngol Head Neck Surgery"},{"issue":"4","key":"2024042306012322200_luae063-B9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/(SICI)1097-0347(199807)20:4<350::AID-HED10>3.0.CO;2-M","article-title":"Spontaneous cervical hemorrhage with near-complete airway obstruction","volume":"20","author":"Chin","year":"1998","journal-title":"Head Neck"},{"issue":"1","key":"2024042306012322200_luae063-B10","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.endonu.2013.04.014","article-title":"Spontaneous neck hematoma due to rupture of parathyroid adenoma: report of 3 cases and literature review","volume":"61","author":"Silla","year":"2014","journal-title":"Endocrinol Nuts"},{"issue":"4","key":"2024042306012322200_luae063-B11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4158\/endp.18.4.21t217n356v6n1w7","article-title":"Spontaneous hemorrhage of a parathyroid adenoma into the mediastinum","volume":"18","author":"Huang","year":"2012","journal-title":"Endocr Pract"},{"issue":"8","key":"2024042306012322200_luae063-B12","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1245\/s10434-010-1003-6","article-title":"Clinical presentation, staging and long-term evolution of parathyroid cancer","volume":"17","author":"Talat","year":"2010","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"2024042306012322200_luae063-B13","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1007\/s00405-020-06004-9","article-title":"Spontaneous neck hematoma secondary to parathyroid adenoma: a case series","volume":"277","author":"Tessler","year":"2020","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"1","key":"2024042306012322200_luae063-B14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12022-013-9294-3","article-title":"Understanding the genetic basis of parathyroid carcinoma","volume":"25","author":"Gill","year":"2014","journal-title":"Endocr Pathol"},{"issue":"4-5","key":"2024042306012322200_luae063-B15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.autrev.2014.01.007","article-title":"Hashimoto thyroiditis: clinical and diagnostic criteria","volume":"13","author":"Caturegli","year":"2014","journal-title":"Autoimmun Rev"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/4\/luae063\/57300778\/luae063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/4\/luae063\/57300778\/luae063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T06:01:40Z","timestamp":1713852100000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae063\/7649928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,3,22]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae063","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,3,22]]},"article-number":"luae063"}}