{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:06Z","timestamp":1753883586148,"version":"3.41.2"},"reference-count":8,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignancies may induce clinical sequelae distant from the sites of the tumor. Such paraneoplastic phenomena are known to affect many organs, including the skin. Vitiligo is a disorder of patchy depigmentation, appearing as white macules with distinct margins. Rarely, vitiligo has been reported as a paraneoplastic occurrence, in the settings of pituitary adenoma, thymoma, gastric carcinoma, and lymphoma. We now describe a man presenting with the abrupt onset of vitiligo on the hands coinciding with recurrence of adrenocortical carcinoma (ACC) in the abdomen. The vitiligo rapidly dissipated following resection of his cancer. We believe this to be the first report of paraneoplastic vitiligo associated with ACC. Endocrinologists typically manage ACC and should be aware of this link, as the de novo observation of vitiligo may signal the onset or recurrence of underlying tumor. Other practitioners that encounter patients with new vitiligo should add ACC to their differential diagnosis of potential underlying conditions.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae070","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T10:08:24Z","timestamp":1714730904000},"source":"Crossref","is-referenced-by-count":0,"title":["Paraneoplastic Vitiligo Associated With Adrenocortical Carcinoma"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-7582","authenticated-orcid":false,"given":"David Alan","family":"Goodkin","sequence":"first","affiliation":[{"name":"Goodkin Biopharma Consulting LLC , Bellevue, WA 98005 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard Alan","family":"Failor","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Nutrition, University of Washington , Seattle, WA 98105 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouhammed Amir","family":"Habra","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center , Houston, TX 77030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"author":"Gale","key":"2024052407044592400_luae070-B1"},{"key":"2024052407044592400_luae070-B2","first-page":"721","volume-title":"Harrison's Principles of Internal Medicine","author":"Jameson","year":"2022","edition":"21st ed"},{"key":"2024052407044592400_luae070-B3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13256-022-03397-5","article-title":"Massive adrenocortical carcinoma presenting as peripheral edema: a case report","volume":"16","author":"Goodkin","year":"2022","journal-title":"J Med Case Reports"},{"issue":"6","key":"2024052407044592400_luae070-B4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000506103","article-title":"Vitiligo: a review","volume":"236","author":"Bergqvist","year":"2020","journal-title":"Dermatol"},{"issue":"8","key":"2024052407044592400_luae070-B5","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1080\/10428190410001683705","article-title":"Vitiligo as a paraneoplastic syndrome preceding pituitary adenoma and subsequent acute lymphoblastic leukemia","volume":"45","author":"Au","year":"2004","journal-title":"Leuk Lymphoma"},{"issue":"1-2","key":"2024052407044592400_luae070-B6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jns.2011.05.038","article-title":"Multiple paraneoplastic syndromes: myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with thymoma","volume":"308","author":"Qiao","year":"2011","journal-title":"J Neurol Sci"},{"issue":"5715","key":"2024052407044592400_luae070-B7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/bmj.3.5715.148","article-title":"Vitiligo and gastric carcinoma","volume":"3","author":"Wright","year":"1970","journal-title":"Br Med J"},{"key":"2024052407044592400_luae070-B8","first-page":"AB140","article-title":"Paraneoplastic autoimmune multiorgan syndrome presenting with vitiligo and lung and liver involvement in the absence of detectable autoantibodies [abstract]","volume":"68","author":"Sanz-Bueno","year":"2013","journal-title":"J Am Acad Dermatol"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/5\/luae070\/57595454\/luae070.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/5\/luae070\/57595454\/luae070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T07:13:20Z","timestamp":1716534800000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae070\/7663644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,4,23]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae070","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,4,23]]},"article-number":"luae070"}}