{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:41:19Z","timestamp":1793040079759,"version":"4.5.0"},"reference-count":12,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We report a case of interstitial nephritis, likely secondary to oxalate nephropathy, due to the development of pancreatic exocrine dysfunction after commencement of pasireotide for acromegaly. Pasireotide is known to impair insulin secretion but can also impair pancreatic exocrine function, hypothezised to result from high-affinity binding of somatostatin receptors 1, 2, 3, and 5. This has been an advantage in postoperative tissue anastomoses after pancreatic surgery, but exocrine insufficiency has not been reported when used for the treatment of acromegaly. A 73-year-old woman, diagnosed with acromegaly, was unable to achieve biochemical control despite 2 surgical resections of an invasive mammosomatotroph pituitary tumor and treatment with cabergoline and maximal-dose lanreotide. The tumor expressed somatostatin receptor type 5 but not somatostatin receptor type 2, predicting good response from pasireotide, which was commenced at 40\u2005mg every 4 weeks. IGF-1 rapidly normalized, but the patient presented with nausea, anorexia, and acute kidney injury. Renal biopsy revealed acute-on-chronic interstitial nephritis, with numerous oxalate crystals. Increased fecal fat globules were noted on fat stain (3+), supporting malabsorption as an etiology of secondary enteric hyperoxaluria. Renal function recovered to near baseline over months following pasireotide withdrawal and high-dose glucocorticoids.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae071","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T16:18:33Z","timestamp":1716221913000},"source":"Crossref","is-referenced-by-count":1,"title":["Acute Interstitial Nephritis and Oxalate Nephropathy After Rapid Pasireotide Response in Treatment-resistant Acromegaly"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-6980","authenticated-orcid":false,"given":"Annabelle G","family":"Hayes","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, St. Vincent's Hospital , Sydney, NSW 2010 , Australia"},{"name":"School of Clinical Medicine, St. Vincent's Campus, Faculty of Medicine and Health, University of New South Wales , Sydney, NSW 2010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Penny","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine and Transplantation, St. Vincent's Hospital , Darlinghurst, NSW 2010 , Australia"},{"name":"School of Medicine, University of Notre Dame , Sydney, NSW 2010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5368-4248","authenticated-orcid":false,"given":"Karina","family":"Aivazian","sequence":"additional","affiliation":[{"name":"Department of Tissue Pathology and Diagnostic Oncology, St. Vincent's Hospital and NSW Health Pathology , Sydney, NSW 2010 , Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney , Sydney, NSW 2050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-0973","authenticated-orcid":false,"given":"Jerry R","family":"Greenfield","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, St. Vincent's Hospital , Sydney, NSW 2010 , Australia"},{"name":"School of Clinical Medicine, St. Vincent's Campus, Faculty of Medicine and Health, University of New South Wales , Sydney, NSW 2010 , Australia"},{"name":"Clinical Diabetes, Appetite and Metabolism Laboratory, Garvan Institute of Medical Research , Sydney, NSW 2010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"issue":"21","key":"2024052016182475900_luae071-B1","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1056\/NEJMoa1313688","article-title":"Pasireotide for postoperative pancreatic fistula","volume":"370","author":"Allen","year":"2014","journal-title":"N Engl J Med"},{"issue":"4","key":"2024052016182475900_luae071-B2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ando.2014.06.004","article-title":"The clinical significance of somatostatin in pancreatic diseases","volume":"75","author":"Sliwi\u0144ska-Mosso\u0144","year":"2014","journal-title":"Ann Endocrinol (Paris)"},{"issue":"2","key":"2024052016182475900_luae071-B3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/ckj\/sfab145","article-title":"Oxalate nephropathy: a review","volume":"15","author":"Rosenstock","year":"2022","journal-title":"Clin Kidney J"},{"issue":"6","key":"2024052016182475900_luae071-B4","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1159\/000517072","article-title":"Secondary oxalate nephropathy: causes and clinicopathological characteristics of a case series","volume":"145","author":"Liang","year":"2021","journal-title":"Nephron"},{"issue":"1","key":"2024052016182475900_luae071-B5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1752-1947-6-215","article-title":"Oxalate nephropathy induced by octreotide treatment for acromegaly: a case report","volume":"6","author":"Gariani","year":"2012","journal-title":"J Med Case Rep"},{"key":"2024052016182475900_luae071-B6","doi-asserted-by":"crossref","first-page":"908542","DOI":"10.3389\/fped.2022.908542","article-title":"Assessment of exocrine pancreatic function in children and adolescents with direct and indirect testing","volume":"10","author":"Hopson","year":"2022","journal-title":"Front Pediatr"},{"issue":"4","key":"2024052016182475900_luae071-B7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1124\/pr.117.015388","article-title":"International union of basic and clinical pharmacology. 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Somatostatin receptors: structure, function, ligands, and new nomenclature","volume":"70","author":"G\u00fcnther","year":"2018","journal-title":"Pharmacol Rev"},{"issue":"6","key":"2024052016182475900_luae071-B8","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1667\/RR2507.1","article-title":"Preclinical evaluation of SOM230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action","volume":"175","author":"Fu","year":"2011","journal-title":"Radiat Res"},{"issue":"21","key":"2024052016182475900_luae071-B9","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1056\/NEJMoa1313688","article-title":"Pasireotide for postoperative pancreatic fistula","volume":"370","author":"Allen","year":"2014","journal-title":"N Engl J Med"},{"issue":"12","key":"2024052016182475900_luae071-B10","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1177\/0003134820947371","article-title":"Meta-Analysis on the effect of pasireotide for prevention of postoperative pancreatic fistula","volume":"86","author":"Dalton","year":"2020","journal-title":"Am Surg"},{"issue":"8","key":"2024052016182475900_luae071-B11","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.cgh.2018.01.027","article-title":"Diagnostic performance of measurement of fecal elastase-1 in detection of exocrine pancreatic insufficiency: systematic review and meta-analysis","volume":"16","author":"Vanga","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"2024052016182475900_luae071-B12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ando.2011.08.001","article-title":"Impact of growth hormone hypersecretion on the adult human kidney","volume":"72","author":"Grunenwald","year":"2011","journal-title":"Ann Endocrinol (Paris)"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/5\/luae071\/57762831\/luae071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/5\/luae071\/57762831\/luae071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T16:18:42Z","timestamp":1716221922000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae071\/7676551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,4,23]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae071","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,4,23]]},"article-number":"luae071"}}