{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:18:37Z","timestamp":1774624717158,"version":"3.50.1"},"reference-count":8,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acromegaly is a rare pituitary condition stemming from hypersecretion of growth hormone (GH). Classic presentation involves enlarged hands, feet, and coarse facial features. However, late-onset cardiac manifestations develop in the absence of disease control. Of the various cardiac complications, heart failure is the rarest (3%-4% of cases). Here we present a case of acromegaly diagnosed after the patient exhibited symptoms of heart failure, with eventual placement of a left ventricular assist device (LVAD) as a bridge to orthotopic heart transplant. The 37-year-old patient originally presented with exercise intolerance and \u201cheavy heartbeats\u201d but was found to be in acute decompensated heart failure, with an ejection fraction (EF) of 15%. The acromegaly diagnosis was confirmed with labs, and he began treatment with lanreotide 120\u2005mg weekly along with 0.5\u2005mg cabergoline twice weekly. EF improved up to 30%. Soon after, he was lost to follow-up during the COVID-19 pandemic and returned with worsening EF. An LVAD was placed to support recovery while the patient awaited heart transplant. While LVADs are a common measure of cardiac support for ischemic cardiomyopathy, they can also be successful options in the setting of GH-driven cardiomegaly.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae072","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T08:42:07Z","timestamp":1715676127000},"source":"Crossref","is-referenced-by-count":2,"title":["Uncontrolled Acromegaly Resulting in the Need for Left Ventricular Assist Device as Bridge to Heart Transplant"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0934-3698","authenticated-orcid":false,"given":"Megana","family":"Murugesh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Thomas Jefferson University Hospital , Philadelphia, PA 19107 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-1589","authenticated-orcid":false,"suffix":"Jr","given":"Franklin Llere\u00f1a","family":"Thelmo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Thomas Jefferson University Hospital , Philadelphia, PA 19107 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika Khanna","family":"Shirodkar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Thomas Jefferson University Hospital , Philadelphia, PA 19107 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"issue":"11","key":"2024051408285155300_luae072-B1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S2213-8587(22)00244-3","article-title":"Acromegaly: pathogenesis, diagnosis, and management","volume":"10","author":"Fleseriu","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"2024051408285155300_luae072-B2","doi-asserted-by":"crossref","first-page":"E251","DOI":"10.1210\/jc.2010-1742","article-title":"Somatotroph tumor progression during pegvisomant therapy: a clinical and molecular study","volume":"96","author":"Marazuela","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2024051408285155300_luae072-B3","volume-title":"Endotext [Internet]","author":"Carroll","year":"2000"},{"key":"2024051408285155300_luae072-B4","doi-asserted-by":"crossref","first-page":"640999","DOI":"10.3389\/fonc.2021.640999","article-title":"Advances in research on the cardiovascular complications of acromegaly","volume":"11","author":"Yang","year":"2021","journal-title":"Front Oncol"},{"issue":"7","key":"2024051408285155300_luae072-B5","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1210\/jcem.87.7.8573","article-title":"Cardiovascular consequences of early-onset growth hormone excess","volume":"87","author":"Colao","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024051408285155300_luae072-B6","first-page":"Article 7","article-title":"Improvement of cardiac function in a patient with heart failure and LVAD placement with treatment of undiagnosed acromegaly","volume":"3","author":"Reddy","year":"2018","journal-title":"Loma Linda University J"},{"issue":"8","key":"2024051408285155300_luae072-B7","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1016\/S0735-1097(23)03640-9","article-title":"An uncommon cause of heart failure: acromegalic cardiomyopathy culminating in orthotopic heart transplantation","volume":"81","author":"Dewanjee","year":"2023","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"2024051408285155300_luae072-B8","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/eurheartj\/14.11.1572","article-title":"Heart transplantation for terminal congestive heart failure in an acromegalic patient","volume":"14","author":"Albat","year":"1993","journal-title":"Eur Heart J"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/5\/luae072\/57595468\/luae072.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/5\/luae072\/57595468\/luae072.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T08:42:14Z","timestamp":1715676134000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae072\/7671227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,4,23]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae072","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,4,23]]},"article-number":"luae072"}}