{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:12:53Z","timestamp":1768291973266,"version":"3.49.0"},"reference-count":22,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We present a unique case of hypokalemic thyrotoxic periodic paralysis (TPP) in an adolescent girl in North America. TPP is a rare but dangerous complication seen in thyrotoxic patients characterized by hypokalemia and acute proximal symmetric lower-extremity weakness. It is an especially rare phenomenon in pediatrics, with roughly 20 case reports described in adolescents worldwide; the majority are male. Our patient is a 14-year-old Asian girl with biochemical hyperandrogenism and known Graves disease who presented with an acute episode of lower-extremity weakness after eating a carbohydrate-rich meal. Laboratory workup revealed hypokalemia, hypomagnesemia, an undetectable thyrotropin, and hyperthyroxinemia. Electrolyte derangements responded well to supplementation, and the muscle weakness resolved with electrolyte normalization. Following improvement in thyroid function, the patient underwent thyroidectomy for definitive management of Graves disease. As TPP is potentially exacerbated by higher androgen and insulin levels, we suspect that with increasing rates of obesity and polycystic ovary syndrome, the incidence of TPP among adolescents may increase. It is therefore critically important that there is awareness and recognition of this serious diagnosis among all health care providers.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae083","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T16:18:32Z","timestamp":1716221912000},"source":"Crossref","is-referenced-by-count":1,"title":["Hyperandrogenism and Hypokalemic Thyrotoxic Periodic Paralysis in a North American Adolescent Girl"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-8198","authenticated-orcid":false,"given":"Anne","family":"Gladding","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology and Diabetes, Medical College of Wisconsin , Milwaukee, WI 53226 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Bartoletti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Emergency Medicine, University of California San Diego (UCSD) , San Diego, CA 92103 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pallavi","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology and Diabetes, Medical College of Wisconsin , Milwaukee, WI 53226 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5385-7310","authenticated-orcid":false,"given":"Elizabeth","family":"Dabrowski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology and Diabetes, Medical College of Wisconsin , Milwaukee, WI 53226 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"issue":"5538","key":"2024052016182431900_luae083-B1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1136\/bmj.1.5538.451","article-title":"Periodic paralysis complicating thyrotoxicosis in Chinese","volume":"1","author":"McFadzean","year":"1967","journal-title":"Br Med J"},{"issue":"12","key":"2024052016182431900_luae083-B2","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1210\/jcem-17-12-1454","article-title":"The association of periodic paralysis and hyperthyroidism in Japan","volume":"17","author":"Okinaka","year":"1957","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024052016182431900_luae083-B3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00005792-199205000-00001","article-title":"Thyrotoxic periodic paralysis in the United States. 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