{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:57Z","timestamp":1753883577829,"version":"3.41.2"},"reference-count":21,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK118942","R01DK118924-02S1","T32DK098107"],"award-info":[{"award-number":["R01DK118942","R01DK118924-02S1","T32DK098107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although clinical guidelines recommend measuring total plasma 25-hydroxyvitamin D (25[OH]D) to assess vitamin D (VitD) status, this index does not account for 3-fold inter-individual variation in VitD binding protein (VDBP) level. We present 3 individuals with total plasma 25(OH)D levels of 10.8 to 12.3\u2005ng\/mL (27-30.7\u2005nmol\/L). Because Endocrine Society guidelines define VitD deficiency as 25(OH)D \u2264 20\u2005ng\/mL (50\u2005nmol\/L), all 3 would be judged to be VitD deficient. VitD3 supplementation increased 25(OH)D to the range of 31.7 to 33.8\u2005ng\/mL (79.1-84.4\u2005nmol\/L). Patient #1 exhibited secondary hyperparathyroidism; VitD3 supplementation decreased parathyroid hormone (PTH) by 34% without a clinically significant change in PTH levels in the other 2 individuals. Thus, 25(OH)D level did not distinguish between the 1 patient who had secondary hyperparathyroidism and the 2 who did not. We therefore inquired whether VitD metabolite ratios (which are VDBP-independent) might distinguish among these 3 individuals. Of all the assessed ratios, the 1,25(OH)2D\/24,25(OH)2D ratio was the most informative, which had a value of 102 pg\/ng in the individual with secondary hyperparathyroidism but lower values (41 and 20 pg\/ng) in the other 2 individuals. These cases illustrate the value of the 1,25(OH)2D\/24,25(OH)2D ratio to provide clinically relevant information about VitD status.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae095","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T09:37:38Z","timestamp":1719567458000},"source":"Crossref","is-referenced-by-count":1,"title":["Value of Vitamin D Metabolite Ratios in 3 Patients as Diagnostic Criteria to Assess Vitamin D Status"],"prefix":"10.1210","volume":"2","author":[{"given":"Zhinous","family":"Shahidzadeh Yazdi","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine , Baltimore, MD 21201 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Streeten","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine , Baltimore, MD 21201 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary B","family":"Whitlatch","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine , Baltimore, MD 21201 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma A","family":"Bargal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine , Baltimore, MD 21201 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber L","family":"Beitelshees","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine , Baltimore, MD 21201 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7500-7854","authenticated-orcid":false,"given":"Simeon I","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine , Baltimore, MD 21201 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"issue":"7","key":"2024072410324997600_luae095-B1","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024072410324997600_luae095-B2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1210\/jc.2011-2218","article-title":"IOM committee members respond to Endocrine Society vitamin D guideline","volume":"97","author":"Rosen","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024072410324997600_luae095-B3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1056\/NEJMoa2202106","article-title":"Supplemental vitamin D and incident fractures in midlife and older adults","volume":"387","author":"LeBoff","year":"2022","journal-title":"N Engl J Med"},{"issue":"8","key":"2024072410324997600_luae095-B4","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1210\/jc.2017-00296","article-title":"Associations of vitamin D-binding globulin and bioavailable vitamin D concentrations with coronary heart disease events: the multi-ethnic study of atherosclerosis (MESA)","volume":"102","author":"Robinson-Cohen","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024072410324997600_luae095-B5","doi-asserted-by":"crossref","first-page":"e10418","DOI":"10.1002\/jbm4.10418","article-title":"The free hormone hypothesis: when, why, and how to measure the free hormone levels to assess vitamin D, thyroid","volume":"5","author":"Bikle","year":"2021","journal-title":"Sex Hormone, and Cortisol Status. 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