{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:35:17Z","timestamp":1773358517577,"version":"3.50.1"},"reference-count":17,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The diagnosis of pheochromocytoma or paraganglioma (PGL) during pregnancy is extremely rare, with 2 large case series suggesting that the prevalence is between 0.0002% and 0.007%. Here, we present a case of a 38-year-old woman who presented during pregnancy with clinical features suggestive of preeclampsia and was found to have a norepinephrine-secreting inferior laryngeal nerve PGL, which was diagnosed after pregnancy. She underwent uncomplicated surgical resection and genetic testing revealed a succinate dehydrogenase subunit B (SDHB) pathogenic variant. In conclusion, PGLs diagnosed during pregnancy and hypersecreting head and neck PGLs are both rare clinical entities. Hyperfunctioning PGLs may mimic pregnancy-induced hypertension or preeclampsia. Metanephrine testing should be considered in patients with atypical features and can be reliably assessed using nonpregnant reference ranges. Overall, maternal and fetal mortality has improved considerably with early diagnosis and treatment.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae107","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T09:37:53Z","timestamp":1719567473000},"source":"Crossref","is-referenced-by-count":1,"title":["Inferior Laryngeal Nerve Paraganglioma With Norepinephrine Hypersecretion Diagnosed Shortly After Pregnancy"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6496-850X","authenticated-orcid":false,"given":"David","family":"Kishlyansky","sequence":"first","affiliation":[{"name":"McMaster University, Division of Endocrinology and Metabolism, Hamilton, ON L8S 4L8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rithvika","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON L8P 1H6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Cook","sequence":"additional","affiliation":[{"name":"McMaster University, Division of Endocrinology and Metabolism, Hamilton, ON L8S 4L8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7643-3252","authenticated-orcid":false,"given":"Meera","family":"Luthra","sequence":"additional","affiliation":[{"name":"McMaster University, Division of Endocrinology and Metabolism, Hamilton, ON L8S 4L8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"issue":"6","key":"2024072410325663200_luae107-B1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMra1806651","article-title":"Pheochromocytoma and paraganglioma","volume":"381","author":"Neumann","year":"2019","journal-title":"N Engl J Med"},{"issue":"2","key":"2024072410325663200_luae107-B2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3803\/EnM.2017.32.2.152","article-title":"Update on modern management of pheochromocytoma and paraganglioma","volume":"32","author":"Lenders","year":"2017","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"6","key":"2024072410325663200_luae107-B3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.oraloncology.2003.09.004","article-title":"Paragangliomas of the head and neck","volume":"40","author":"Pellitteri","year":"2004","journal-title":"Oral Oncol"},{"issue":"5","key":"2024072410325663200_luae107-B4","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1245\/s10434-020-08220-3","article-title":"Update on pheochromocytoma and paraganglioma from the SSO endocrine\/head and neck disease-site work group. Part 1 of 2: advances in pathogenesis and diagnosis of pheochromocytoma and paraganglioma","volume":"27","author":"Patel","year":"2020","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"2024072410325663200_luae107-B5","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1002\/hed.26277","article-title":"Head and neck paragangliomas: 30-year experience","volume":"42","author":"Valero","year":"2020","journal-title":"Head Neck"},{"key":"2024072410325663200_luae107-B6","first-page":"11","article-title":"Carotid and vagal body paragangliomas","volume":"6","author":"Del Guercio","year":"2013","journal-title":"Transl Med UniSa"},{"issue":"7","key":"2024072410325663200_luae107-B7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/09513590.2020.1754392","article-title":"Pheochromocytoma diagnosed during pregnancy: a case report","volume":"36","author":"Misasi","year":"2020","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"2024072410325663200_luae107-B8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/BF03345503","article-title":"Diagnosis and management of pheochromocytoma during pregnancy","volume":"25","author":"Mannelli","year":"2002","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"2024072410325663200_luae107-B9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11886-021-01485-4","article-title":"Pheochromocytoma and paraganglioma in pregnancy: a new era","volume":"23","author":"Gruber","year":"2021","journal-title":"Curr Cardiol Rep"},{"issue":"3","key":"2024072410325663200_luae107-B10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41574-023-00926-0","article-title":"Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert consensus statement","volume":"20","author":"Ta\u00efeb","year":"2024","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"2024072410325663200_luae107-B11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4103\/sajc.sajc_339_18","article-title":"Head-and-neck paragangliomas: an overview of 54 cases operated at a tertiary care center","volume":"8","author":"Singh","year":"2019","journal-title":"South Asian J Cancer"},{"issue":"1","key":"2024072410325663200_luae107-B12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S2213-8587(20)30363-6","article-title":"Maternal and fetal outcomes in phaeochromocytoma and pregnancy: a multicentre retrospective cohort study and systematic review of literature","volume":"9","author":"Bancos","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"2024072410325663200_luae107-B13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.surg.2016.05.050","article-title":"SDHB mutation status and tumor size but not tumor grade are important predictors of clinical outcome in pheochromocytoma and abdominal paraganglioma","volume":"161","author":"Assadipour","year":"2017","journal-title":"Surgery"},{"issue":"2","key":"2024072410325663200_luae107-B14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1530\/EJE-11-0528","article-title":"Pheochromocytoma and pregnancy: a deceptive connection","volume":"166","author":"Lenders","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2024072410325663200_luae107-B15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1210\/endrev\/bnab019","article-title":"Personalized management of pheochromocytoma and paraganglioma","volume":"43","author":"N\u00f6lting","year":"2022","journal-title":"Endocr Rev"},{"issue":"12","key":"2024072410325663200_luae107-B16","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1471-0528.1982.tb04661.x","article-title":"Plasma noradrenaline and Adrenaline levels in normal pregnancy and in pregnancy-induced hypertension","volume":"89","author":"Natrajan","year":"1982","journal-title":"Br J Obstet Gynaecol"},{"issue":"11","key":"2024072410325663200_luae107-B17","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/00006254-197111000-00001","article-title":"Pheochromocytoma and pregnancy. 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