{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:43:26Z","timestamp":1790801006609,"version":"4.1.0"},"reference-count":14,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Primary hyperparathyroidism in pregnancy is uncommon. Consequently, there are no randomized controlled studies that address treatment of primary hyperparathyroidism in pregnancy, and the efficacy and safety of medical management with cinacalcet in this setting is unknown. We report a case of a 28-year-old woman with primary hyperparathyroidism and hypercalcemia that worsened during her third trimester of pregnancy. Cinacalcet led to achievement of normocalcemia, allowing the delay of parathyroidectomy until after delivery of the baby. We also review the published literature on cinacalcet use in the management of primary hyperparathyroidism during pregnancy. Cinacalcet is typically reserved for pregnant patients with severe and symptomatic hypercalcemia, primarily serving as a last resort to delay parathyroidectomy until either the second trimester or the postpartum period.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae117","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T06:24:38Z","timestamp":1721024678000},"source":"Crossref","is-referenced-by-count":6,"title":["Use of Cinacalcet for the Management of Primary Hyperparathyroidism in Pregnancy"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9418-9133","authenticated-orcid":false,"given":"Elissa","family":"Foster","sequence":"first","affiliation":[{"name":"Nephrology Division, Baylor University Medical Center , Dallas, TX 75246 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-283X","authenticated-orcid":false,"given":"Naim M","family":"Maalouf","sequence":"additional","affiliation":[{"name":"Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, UT Southwestern Medical Center , Dallas, TX 75390-8885 , USA"},{"name":"Department of Internal Medicine, UT Southwestern Medical Center , Dallas, TX 75390-8885 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"issue":"2","key":"2024072410335704000_luae117-B1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1152\/physrev.00027.2015","article-title":"Maternal mineral and bone metabolism during pregnancy, lactation, and post-weaning recovery","volume":"96","author":"Kovacs","year":"2016","journal-title":"Physiol Rev"},{"issue":"13","key":"2024072410335704000_luae117-B2","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.3390\/jcm10132956","article-title":"Primary hyperparathyroidism in pregnancy: literature review of the diagnosis and management","volume":"10","author":"Ali","year":"2021","journal-title":"J Clin Med"},{"issue":"5","key":"2024072410335704000_luae117-B3","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/0002-9378(75)90481-0","article-title":"Calcium metabolism in pregnancy: a review","volume":"121","author":"Pitkin","year":"1975","journal-title":"Am J Obstet Gynecol"},{"key":"2024072410335704000_luae117-B4","author":"Highlights of Prescribing Information"},{"issue":"2","key":"2024072410335704000_luae117-B5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00404-014-3526-8","article-title":"Primary hyperparathyroidism during pregnancy","volume":"291","author":"Dochez","year":"2015","journal-title":"Arch Gynecol Obstet"},{"key":"2024072410335704000_luae117-B6","first-page":"140056","article-title":"The use of cinacalcet in pregnancy to treat a complex case of parathyroid carcinoma","volume":"2014","author":"Nadarasa","year":"2014","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"issue":"1","key":"2024072410335704000_luae117-B7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/01443615.2017.1325862","article-title":"Primary hyperparathyroidism in pregnancy treated with cinacalcet: a case report","volume":"38","author":"Gonzalo Garc\u00eda","year":"2018","journal-title":"J Obstet Gynaecol"},{"issue":"9","key":"2024072410335704000_luae117-B8","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1210\/js.2017-00172","article-title":"Gestational primary hyperparathyroidism due to ectopic parathyroid adenoma: case report and literature review","volume":"1","author":"Horton","year":"2017","journal-title":"J. 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Med Case Rep"},{"issue":"1","key":"2024072410335704000_luae117-B10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/08998280.2020.1834791","article-title":"Treatment approach for primary hyperparathyroidism in pregnancy","volume":"34","author":"Latif","year":"2020","journal-title":"Proc Bayl Univ Med Cent"},{"issue":"3","key":"2024072410335704000_luae117-B11","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s12020-022-03127-3","article-title":"Different treatment strategies in primary hyperparathyroidism during pregnancy","volume":"77","author":"Eremkina","year":"2022","journal-title":"Endocrine"},{"issue":"2","key":"2024072410335704000_luae117-B12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.14740\/jem624","article-title":"Medical management of primary hyperparathyroidism in pregnancy: a case report and brief literature review","volume":"10","author":"Ning","year":"2020","journal-title":"J Endocrinol Metab"},{"issue":"8","key":"2024072410335704000_luae117-B13","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1515\/JPEM.2009.22.8.741","article-title":"Cinacalcet for hyperparathyroidism in pregnancy and puerperium","volume":"22","author":"Horjus","year":"2009","journal-title":"J Ped Endocrinol Metab"},{"issue":"1","key":"2024072410335704000_luae117-B14","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.4158\/ACCR-2018-0230","article-title":"A case of hyperparathyroidism treated with cinacalcet during pregnancy","volume":"5","author":"Bashir","year":"2019","journal-title":"AACE Clin Case Rep"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/7\/luae117\/58625940\/luae117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/7\/luae117\/58625940\/luae117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T02:34:58Z","timestamp":1721874898000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae117\/7713613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,6,27]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae117","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,6,27]]},"article-number":"luae117"}}