{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:37Z","timestamp":1753883617415,"version":"3.41.2"},"reference-count":16,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We present a case of a PTH-related peptide (PTH-rp) producing uterine myoma, leading to hypercalcemia in pregnancy. Our patient presented with dehydration, hypotension, delirium, and malnutrition. Due to a serum calcium level of 17.9 mg\/dL (4.48 mmol\/L) (reference range 8.8-11.2 mg\/dL; 2.20-2.80 mmol\/L), prompt treatment with hydration and calcitonin was initiated. The patient went into labor before we could consider other treatment options. Although uncommon in pregnancy, it is of great importance to identify hypercalcemia since it is related to a high risk of maternal and neonatal morbidity and mortality. Because bisphosphonates are contraindicated in pregnancy, hydration and calcitonin are the cornerstones of treatment for PTH-rp-induced hypercalcemia.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae126","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T09:32:27Z","timestamp":1723627947000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypercalcemia in Pregnancy Caused by a Uterine Myoma"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7679-0382","authenticated-orcid":false,"given":"Stephanie","family":"van der Leij","sequence":"first","affiliation":[{"name":"Department of Endocrinology, University Medical Center, Utrecht University , Utrecht, CX 3584 , The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology , Utrecht, CS 3584 , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doenja","family":"Hertog","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Medical Center, Utrecht University , Utrecht, CX 3584 , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"issue":"2","key":"2024091803561841700_luae126-B1","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1530\/EJE-21-1044","article-title":"European expert consensus on practical management of specific aspects of parathyroid disorders in adults and in pregnancy: recommendations of the ESE Educational Program of Parathyroid Disorders","volume":"186","author":"Bollerslev","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"2024091803561841700_luae126-B2","first-page":"19-0039","article-title":"Management of primary hyperparathyroidism in pregnancy: a case series","volume":"2019","author":"McCarthy","year":"2019","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"issue":"6","key":"2024091803561841700_luae126-B3","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1210\/clinem\/dgac734","article-title":"Approach to the patient: management of parathyroid diseases across pregnancy","volume":"108","author":"Appelman-Dijkstra","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024091803561841700_luae126-B4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ecl.2011.08.002","article-title":"Calcium and bone metabolism disorders during pregnancy and lactation","volume":"40","author":"Kovacs","year":"2011","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"3","key":"2024091803561841700_luae126-B5","first-page":"784","article-title":"Relative overexpression of the parathyroid hormone-related protein gene in human leiomyomas","volume":"78","author":"Weir","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024091803561841700_luae126-B6","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1210\/endo-128-5-2317","article-title":"In vivo regulation of parathyroid hormone-related peptide messenger ribonucleic acid in the rat uterus by 17 beta-estradiol","volume":"128","author":"Thiede","year":"1991","journal-title":"Endocrinology"},{"issue":"2","key":"2024091803561841700_luae126-B7","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1161\/HYP.0000000000000208","article-title":"Hypertension in pregnancy: diagnosis, blood pressure goals, and pharmacotherapy: a scientific statement from the American Heart Association","volume":"79","author":"Garovic","year":"2022","journal-title":"Hypertension"},{"issue":"23","key":"2024091803561841700_luae126-B8","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2146\/ajhp140041","article-title":"Effects of maternal bisphosphonate use on fetal and neonatal outcomes","volume":"71","author":"Green","year":"2014","journal-title":"Am J Health Syst Pharm"},{"issue":"1","key":"2024091803561841700_luae126-B9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00198-018-4672-9","article-title":"Pregnancy and newborn outcomes after exposure to bisphosphonates: a case-control study","volume":"30","author":"Sokal","year":"2019","journal-title":"Osteoporos Int"},{"issue":"4","key":"2024091803561841700_luae126-B10","doi-asserted-by":"crossref","first-page":"280","DOI":"10.14310\/horm.2002.1319","article-title":"The use of bisphosphonates in women prior to or during pregnancy and lactation","volume":"10","author":"Stathopoulos","year":"2011","journal-title":"Hormones (Athens)"},{"issue":"2","key":"2024091803561841700_luae126-B11","article-title":"Clinical evidence of the effect of bisphosphonates on pregnancy and the infant","volume":"40","author":"MacHairiotis","year":"2019","journal-title":"Horm Mol Biol Clin Investig"},{"issue":"4","key":"2024091803561841700_luae126-B12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/qjmed\/hcn010","article-title":"Humoral hypercalcaemia of benignancy. A case report","volume":"101","author":"Herring","year":"2008","journal-title":"QJM"},{"key":"2024091803561841700_luae126-B13","doi-asserted-by":"crossref","first-page":"e923412","DOI":"10.12659\/AJCR.923412","article-title":"Hypercalcemia resulting from necrotizing leiomyoma in a pregnant female","volume":"21","author":"Kropf","year":"2020","journal-title":"Am J Case Rep"},{"issue":"10","key":"2024091803561841700_luae126-B14","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/ccr3.646","article-title":"Hypercalcemia in pregnancy\u2014a multifaceted challenge: case reports and literature review","volume":"4","author":"Rey","year":"2016","journal-title":"Clin Case Rep"},{"issue":"1","key":"2024091803561841700_luae126-B15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0974-2700.93093","article-title":"Humoral hypercalcemic crisis in a pregnant woman with uterine leiomyoma","volume":"5","author":"Rahil","year":"2012","journal-title":"J Emerg Trauma Shock"},{"issue":"4","key":"2024091803561841700_luae126-B16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1530\/eje.0.1370402","article-title":"Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: a longitudinal study","volume":"137","author":"Ardawi","year":"1997","journal-title":"Eur J Endocrinol"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/9\/luae126\/59132829\/luae126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/2\/9\/luae126\/59132829\/luae126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T03:56:33Z","timestamp":1726631793000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luae126\/7733123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,14]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,8,14]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luae126","relation":{},"ISSN":["2755-1520"],"issn-type":[{"type":"electronic","value":"2755-1520"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,8,14]]},"article-number":"luae126"}}