{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:37Z","timestamp":1787169937544,"version":"build-2736575974"},"reference-count":18,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurosarcoidosis (NS) with hypothalamic-pituitary (HP) involvement (HP-NS) is a rare clinical condition, conferring variable hormonal deficits that are typically irreversible. Here, we present 2 cases of NS with panhypopituitarism. The first patient presented with cauda equina syndrome and arginine vasopressin deficiency, while the second developed recurrent optic neuritis and vision loss in the setting of a sellar mass. In the first case, neurological symptoms resolved after therapy with high-dose glucocorticoids, infliximab, and methotrexate; while in the second, visual restoration followed resection of the granulomatous tissue and immunosuppressive therapy. In both cases, pituitary dysfunction persisted despite neurological improvement. We contextualized the presentations and outcomes through a literature review of HP-NS case reports and case series. This revealed high rates of extraneurologic sarcoidosis in HP-NS patients with panhypopituitarism, while underscoring the need for hormonal replacement\u2014as endocrinopathies rarely respond to sarcoidosis-directed immunosuppression.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae141","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T01:09:40Z","timestamp":1720832980000},"source":"Crossref","is-referenced-by-count":6,"title":["Neurosarcoidosis With Panhypopituitarism: Two Cases and Literature Review"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7811-9607","authenticated-orcid":false,"given":"Ewelina","family":"Niedzialkowska","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Corewell Health William Beaumont University Hospital , Royal Oak, MI 48073 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Blazin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Corewell Health William Beaumont University Hospital , Royal Oak, MI 48073 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Shelden","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Corewell Health William Beaumont University Hospital , Royal Oak, MI 48073 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D","family":"Buras","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes (MEND), Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"issue":"9","key":"2024081401415403200_luae141-B1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1001\/archneur.1985.04060080095022","article-title":"Sarcoidosis and its neurological manifestations","volume":"42","author":"Stern","year":"1985","journal-title":"Arch Neurol"},{"issue":"10","key":"2024081401415403200_luae141-B2","doi-asserted-by":"crossref","first-page":"e524","DOI":"10.1016\/j.lpm.2012.01.038","article-title":"Sarco\u00efdose: l'atteinte des hormones \u00e0 d\u00e9pendance ant\u00e9hypophysaire est insuffisamment diagnostiqu\u00e9e [Sarcoidosis: the involvement of anterior pituitary hormones is poorly recognized]","volume":"41","author":"Bihan","year":"2012","journal-title":"Presse 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with sarcoidosis manifesting panhypopituitarism with central diabetes insipidus","volume":"54","author":"Miyoshi","year":"2007","journal-title":"Endocr J"},{"issue":"3","key":"2024081401415403200_luae141-B12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1385\/ENDO:17:3:241","article-title":"Isolated neurosarcoidosis\u2013a diagnostic enigma: case report and discussion","volume":"17","author":"Randeva","year":"2002","journal-title":"Endocrine"},{"issue":"3","key":"2024081401415403200_luae141-B13","first-page":"464","article-title":"Osseous and central nervous system sarcoidosis: scintigraphic and radiographic findings","volume":"36","author":"Sweeney","year":"1995","journal-title":"J Nucl Med"},{"issue":"5","key":"2024081401415403200_luae141-B14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00000441-198711000-00011","article-title":"A case of hypothalamic sarcoidosis with hypopituitarism and prolonged remission of 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