{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:09:32Z","timestamp":1783123772246,"version":"3.54.6"},"reference-count":25,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cardiac tamponade is a rare complication of hypothyroidism. In rarer cases, hypothyroidism may initially present with tamponade. Cardiac tamponade is an emergency condition that usually requires urgent intervention. However, guidelines for tamponade secondary to hypothyroidism are not optimal, and cases have been managed variably (ranging from levothyroxine alone to pericardiocentesis followed by thyroid hormone replacement) with diverse outcomes. Here, we report a case of a 42-year-old male with no medical history who presented with exertional dyspnea, lower leg swelling, facial puffiness, constipation, and weight gain. He had low blood pressure (80\/60\u2005mm Hg), normal heart rate with sinus rhythm, normal oxygen saturation, and was afebrile. Apart from a mildly raised creatinine, his test results were normal. An echocardiogram revealed features of tamponade. Further laboratory tests showed severe hypothyroidism. Following the initiation of levothyroxine, he demonstrated significant improvement. Coronary angiography revealed 95% stenosis in the mid-left anterior descending artery, treated with stenting. Serial echocardiograms showed regression of the pericardial effusion, stabilizing his condition without the need for invasive pericardiocentesis. This case highlights the importance of prompt diagnosis and management of hypothyroidism-related tamponade to prevent severe cardiac compromise. Hence, it may be necessary to consider hypothyroidism in the differential for patients with unexplained cardiac tamponade.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae150","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:22:04Z","timestamp":1724458924000},"source":"Crossref","is-referenced-by-count":1,"title":["Cardiac Tamponade as a Harbinger of Hypothyroidism"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7121-8574","authenticated-orcid":false,"given":"Fateen","family":"Ata","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hamad Medical Corporation , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Al-Hattab","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hamad Medical Corporation , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0219-1678","authenticated-orcid":false,"given":"Ammara","family":"Bint I Bilal","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hamad Medical Corporation , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9854-918X","authenticated-orcid":false,"given":"Ezeddin","family":"Alataresh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hamad Medical Corporation , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2786-9650","authenticated-orcid":false,"given":"Haval","family":"Surchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hamad Medical Corporation , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"issue":"25","key":"2024091803571371200_luae150-B1","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1161\/CIRCULATIONAHA.118.036859","article-title":"Thyroid and cardiovascular disease: research agenda for enhancing knowledge, prevention, and treatment","volume":"139","author":"Cappola","year":"2019","journal-title":"Circulation"},{"issue":"3","key":"2024091803571371200_luae150-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytaa071","article-title":"Cardiac tamponade due to primary hypothyroidism: acute management and approach to prevent recurrence\u2014a case report","volume":"4","author":"Maddali","year":"2020","journal-title":"Eur Heart J Case Rep"},{"issue":"6","key":"2024091803571371200_luae150-B3","doi-asserted-by":"crossref","first-page":"683.e1","DOI":"10.1016\/j.ajem.2013.11.038","article-title":"Cardiac tamponade as initial presenting feature of primary hypothyroidism in the ED","volume":"32","author":"Ekka","year":"2014","journal-title":"Am J Emerg Med"},{"issue":"1","key":"2024091803571371200_luae150-B4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1524-6175.2007.06343.x","article-title":"Hypertensive emergency with cardiac tamponade associated with hypothyroidism","volume":"9","author":"Handler","year":"2007","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2024091803571371200_luae150-B5","doi-asserted-by":"crossref","first-page":"bcr2013201472","DOI":"10.1136\/bcr-2013-201472","article-title":"Recurrent cardiac tamponade in a young woman","volume":"2013","author":"Itolikar","year":"2013","journal-title":"BMJ Case Rep"},{"issue":"11","key":"2024091803571371200_luae150-B6","doi-asserted-by":"crossref","first-page":"A1155","DOI":"10.1016\/S0735-1097(18)31696-6","article-title":"Cardiac tamponade incidence, demographics and in-hospital outcomes: analysis of the national inpatient sample database","volume":"71","author":"Al-Ogaili","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"2024091803571371200_luae150-B7","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1378\/chest.104.5.1632","article-title":"Massive macroglossia as a presenting feature of hypothyroid-associated pericardial effusion","volume":"104","author":"Meares","year":"1993","journal-title":"Chest"},{"issue":"1","key":"2024091803571371200_luae150-B8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0300-8932(00)75075-5","article-title":"[Pericardial tamponade as the first manifestation of primary hypothyroidism]","volume":"53","author":"Jimeno Sainz","year":"2000","journal-title":"Rev Esp Cardiol"},{"issue":"2","key":"2024091803571371200_luae150-B9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.7861\/clinmedicine.17-2-140","article-title":"Getting to the heart of hypopituitarism","volume":"17","author":"Martin-Grace","year":"2017","journal-title":"Clin Med (Lond)"},{"issue":"6","key":"2024091803571371200_luae150-B10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/clc.4960160612","article-title":"Hypothyroid cardiac tamponade presenting with severe systemic hypertension","volume":"16","author":"Machado","year":"1993","journal-title":"Clin Cardiol"},{"issue":"11","key":"2024091803571371200_luae150-B11","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1111\/j.1532-5415.2010.03132.x","article-title":"Elderly woman with massive pericardial effusion, cardiac tamponade, and hypothyroidism","volume":"58","author":"Luis Cuitlhuac","year":"2010","journal-title":"J Am Geriatr Soc"},{"issue":"12","key":"2024091803571371200_luae150-B12","first-page":"e6393","article-title":"Hypothyroidism causing pericardial effusion: a case 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