{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:56:52Z","timestamp":1788886612626,"version":"build-2803163510"},"reference-count":10,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Euglycemic ketoacidosis is a medical emergency characterized by euglycemia, metabolic acidosis, and ketonemia. It is a well-recognized adverse event in patients with diabetes taking sodium-glucose cotransporter-2 inhibitors. However, little has been reported about euglycemic ketoacidosis using glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide. We present a case of euglycemic ketoacidosis in a young female without diabetes who was taking semaglutide for weight loss for the last 7 months. She was treated with bicarbonate-containing dextrose infusion, which improved the ketoacidosis rapidly. The incidence of euglycemic ketoacidosis will likely increase with the increasing use of GLP-1 inhibitors, and recognizing the signs and symptoms of this life-threatening condition is essential to treat it effectively. Our literature search identified 1 reported case of euglycemic ketoacidosis in a patient without diabetes associated with tirzepatide but none with semaglutide.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae156","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T06:57:57Z","timestamp":1725001077000},"source":"Crossref","is-referenced-by-count":14,"title":["Euglycemic Ketoacidosis From Semaglutide in a Patient Without Diabetes"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9456-5828","authenticated-orcid":false,"given":"Nikhil","family":"Sood","sequence":"first","affiliation":[{"name":"Department of Hospital Medicine, Banner Health , Gilbert, AZ 85234 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ojas","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Banner Health , Mesa, AZ 85202 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, CHI Health Mercy Hospital , Council Bluffs, IA 51503 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Hoskote","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, WellSpan York Hospital , York, PA 17403 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"issue":"4","key":"2024091803572294500_luae156-B1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/pdi.1769","article-title":"Euglycaemic ketoacidosis in patients with and without diabetes","volume":"30","author":"Le Neveu","year":"2013","journal-title":"Pract Diabetes"},{"issue":"1","key":"2024091803572294500_luae156-B2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/jim-2021-001952","article-title":"Wegovy (semaglutide): a new weight loss drug for chronic weight management","volume":"70","author":"Singh","year":"2022","journal-title":"J Investig Med"},{"issue":"3","key":"2024091803572294500_luae156-B3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/dom.12824","article-title":"Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: a systematic analysis of published clinical trials","volume":"19","author":"Bettge","year":"2017","journal-title":"Diabetes Obes Metab"},{"key":"2024091803572294500_luae156-B4","doi-asserted-by":"crossref","first-page":"645563","DOI":"10.3389\/fendo.2021.645563","article-title":"Safety of semaglutide [published correction appears in Front Endocrinol (Lausanne). 2021 Nov 10; 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