{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:10:40Z","timestamp":1784005840237,"version":"3.55.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Insulinomas are rare insulin-secreting tumors that most commonly affect adults. A 26-month-old child presented to her local emergency department with severe hypoglycemia. Initial workup was consistent with hyperinsulinemic hypoglycemia. Over the course of 10 months, multiple therapies for hyperinsulinism (HI) were trialed without significant benefit. Genetic testing for genes associated with HI was negative. At age 35 months, the patient was transferred to our center for further treatment. She underwent several imaging tests that revealed a lesion on her pancreas concerning for an insulinoma. The patient underwent surgical intervention to enucleate the lesion. Histopathological review of the specimen confirmed a benign, well-circumscribed insulinoma. A postoperative fasting test proved the patient was cured and she was discharged without the need for further glucose monitoring.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae161","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T04:21:16Z","timestamp":1726460476000},"source":"Crossref","is-referenced-by-count":2,"title":["Hyperinsulinemic Hypoglycemia Due to an Insulinoma in a 2-Year-Old Child"],"prefix":"10.1210","volume":"2","author":[{"given":"Lauren M","family":"Mitteer","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"},{"name":"Congenital Hyperinsulinism Center, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"States","sequence":"additional","affiliation":[{"name":"Congenital Hyperinsulinism Center, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"},{"name":"Department of Radiology, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Congenital Hyperinsulinism Center, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"},{"name":"Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School Medicine at the University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Scott","family":"Adzick","sequence":"additional","affiliation":[{"name":"Congenital Hyperinsulinism Center, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"},{"name":"Department of Surgery, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lord","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"},{"name":"Congenital Hyperinsulinism Center, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"},{"name":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-8087","authenticated-orcid":false,"given":"Diva D","family":"De Le\u00f3n","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"},{"name":"Congenital Hyperinsulinism Center, Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"},{"name":"Department of Pediatrics, 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