{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:47Z","timestamp":1753883567332,"version":"3.41.2"},"reference-count":30,"publisher":"The Endocrine Society","issue":"11","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Z1AHD008735"],"award-info":[{"award-number":["Z1AHD008735"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Intramural Research Program of the National Institutes of Health"},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We present a unique case of primary intraosseous paraganglioma (PGL) originating from maxillary bone. PGL is a neurosecretory neoplasm that arises from cells believed to originate from the neural crest. A 30-year-old woman presented with right facial pain and swelling, along with palpitations. Computed tomography (CT) imaging revealed a 3.3 \u00d7 3.1 \u00d7 2.3\u2005cm mass in the anterior maxilla, and biochemical results showed elevated plasma dopamine, 3-methoxytyramine, and chromogranin A levels. Biopsy confirmed a PGL, with positive expression of synaptophysin, chromogranin A, and GATA-3. Whole-body positron emission tomography\/computed tomography (PET\/CT) scans showed avidity on 18F-fluorodopa (18F-FDOPA), 68Ga-DOTA(0)-Tyr(3)-octreotate \u200b\u200b (68Ga-DOTATATE), and 18F-fluorodeoxyglucose (18F-FDG). No other lesions (primary or metastatic) were found. Proton beam therapy was chosen over surgery due to potential complications and patient's preference. Following radiotherapy, she experienced symptom relief, with dopamine levels decreasing and chromogranin A normalizing, with the lesion remaining stable on 11-month follow-up imaging. This case highlights the rarity of primary bone PGLs and underscores the importance of comprehensive diagnostic approaches combining physical examinations, biochemical testing, functional imaging, and histopathological analysis properly guiding personalized treatment strategies. Additionally, proton beam therapy emerges as a highly suitable treatment option for head and neck paragangliomas (HNPGLs), offering effective tumor control with minimal complications.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae181","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T09:26:36Z","timestamp":1729243596000},"source":"Crossref","is-referenced-by-count":1,"title":["Primary Paraganglioma Arising From the Maxillary Bone"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2484-1634","authenticated-orcid":false,"given":"Elias","family":"Chuki","sequence":"first","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases\/National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimia","family":"Saleh Anaraki","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Maryland Capital Region , Largo, MD 20774 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-2471","authenticated-orcid":false,"given":"Abhishek","family":"Jha","sequence":"additional","affiliation":[{"name":"Section on Medical Neuroendocrinology, Eunice Kennedy Shriver NICHD, NIH , Bethesda, MD 20892-1109 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayank","family":"Patel","sequence":"additional","affiliation":[{"name":"Section on Medical Neuroendocrinology, Eunice Kennedy Shriver NICHD, NIH , Bethesda, MD 20892-1109 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Ling","sequence":"additional","affiliation":[{"name":"Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health , Bethesda, MD 20892 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