{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:47Z","timestamp":1753883567615,"version":"3.41.2"},"reference-count":20,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thyrotroph hyperplasia is commonly present but remains largely undiagnosed in primary hypothyroidism. It is easily reversible with thyroid replacement therapy. If imaging is performed prior to biochemical evaluation, then patients may undergo pituitary surgery unnecessarily. We present the case of a 30-year-old man with thyrotroph hyperplasia caused by profound primary hypothyroidism leading to hypopituitarism that resolved after levothyroxine replacement therapy. We will discuss the current literature regarding pituitary hyperplasia in primary hypothyroidism in adults.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae187","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T15:50:35Z","timestamp":1729093835000},"source":"Crossref","is-referenced-by-count":0,"title":["Thyrotroph Hyperplasia Caused by Severe Primary Hypothyroidism Leading to Adrenal Crisis"],"prefix":"10.1210","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9863-3135","authenticated-orcid":false,"given":"Yasser","family":"Hakami","sequence":"first","affiliation":[{"name":"Obesity, Endocrine and Metabolism Center, King Fahad Medical City , Riyadh 12231 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz","family":"AlJaman","sequence":"additional","affiliation":[{"name":"Endocrine Department, King Saud Medical Complex , Riyadh 12746 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"issue":"3-4","key":"2024102310042587300_luae187-B1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1009952930425","article-title":"Pituitary hyperplasia","volume":"1","author":"Horvath","year":"1999","journal-title":"Pituitary"},{"key":"2024102310042587300_luae187-B2","first-page":"150017","article-title":"Pituitary hyperplasia: case series and literature review of an under-recognised and heterogeneous condition","volume":"2015","author":"De Sousa","year":"2015","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"issue":"8","key":"2024102310042587300_luae187-B3","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s00701-012-1342-0","article-title":"Pituitary tumorous hyperplasia due to primary hypothyroidism","volume":"154","author":"Han","year":"2012","journal-title":"Acta Neurochir (Wien)"},{"issue":"6","key":"2024102310042587300_luae187-B4","first-page":"610","article-title":"Thyrotropin-secreting pituitary tumors","volume":"17","author":"Beck-Peccoz","year":"1996","journal-title":"Endocr Rev"},{"issue":"2","key":"2024102310042587300_luae187-B5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1148\/radiology.213.2.r99nv02383","article-title":"Rapid progression of pituitary hyperplasia in humans with primary hypothyroidism: demonstration with MR imaging","volume":"213","author":"Shimono","year":"1999","journal-title":"Radiology"},{"volume-title":"Trait\u00e9 du Goitre et du Cr\u00e9tinisme","year":"1851","author":"Niepce","key":"2024102310042587300_luae187-B6"},{"issue":"2","key":"2024102310042587300_luae187-B7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/path.1700010209","article-title":"Enlargement of the hypophysis associated with changes in the thyroid body","volume":"1","author":"Boyce","year":"1982","journal-title":"J Pathol Bacteriol"},{"issue":"4","key":"2024102310042587300_luae187-B8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/BF03351025","article-title":"Pituitary thyrotroph hyperplasia mimicking prolactin-secreting adenoma","volume":"7","author":"Khalil","year":"1984","journal-title":"J Endocrinol Invest"},{"key":"2024102310042587300_luae187-B9","first-page":"499","article-title":"Pituitary gland in hypothyroidism. 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