{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:03:12Z","timestamp":1768075392429,"version":"3.49.0"},"reference-count":16,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lymphocytic infundibuloneurohypophysitis (LINH) is a disease with an etiology involving an autoimmune mechanism, characterized by lymphocytic inflammation of the posterior pituitary and infundibular stalk, resulting in arginine vasopressin deficiency. It is difficult to distinguish from pituitary neoplasm or infiltrative diseases, and biopsy is necessary for a definitive diagnosis, but this is highly invasive. In children, it is especially important to distinguish LINH from tumors such as germ cell tumors. Recently, the usefulness of anti-rabphilin-3A antibody as a serum marker for LINH has been reported. To date, only a limited number of pediatric cases have been reported. We present a 4-year-old boy with arginine vasopressin deficiency. Magnetic resonance imaging of the head showed thickening of the pituitary stalk without a posterior pituitary bright spot, and anti-rabphilin-3A antibody was positive. Consequently, pituitary biopsy was not performed because of the strong suspicion of LINH. Five months after symptom onset, the pituitary stalk thickening had resolved. This case represents the first report of probable or definitive LINH with anti-rabphilin-3A antibody positivity in a 4-year-old child, making it the youngest positive case reported to date. Our case highlights the importance of noninvasive approaches and careful follow-up to avoid invasive interventions for children with LINH.<\/jats:p>","DOI":"10.1210\/jcemcr\/luae214","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:20:50Z","timestamp":1730809250000},"source":"Crossref","is-referenced-by-count":1,"title":["A 4-year-old Boy Positive for Anti-rabphilin-3A Antibody and Diagnosed With Lymphocytic Infundibuloneurohypophysitis"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7385-0140","authenticated-orcid":false,"given":"Akiko","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Division of Pediatrics, Kumamoto Chuo Hospital , Kumamoto 862-0965 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagisa","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Kumamoto Chuo Hospital , Kumamoto 862-0965 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Daido Hospital, Nagoya , Aichi 457-8511 ,","place":["Japan"]},{"name":"Department of Endocrinology, Diabetes and Metabolism, School of Medicine, Fujita Health University , Aichi 470-1192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, School of Medicine, Fujita Health University , Aichi 470-1192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, School of Medicine, Fujita Health University , Aichi 470-1192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Sugimura","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, School of Medicine, Fujita Health University , Aichi 470-1192 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"2025011704220893800_luae214-B1","doi-asserted-by":"crossref","first-page":"868558","DOI":"10.3389\/fendo.2022.868558","article-title":"Pituitary stalk thickening: causes and consequences. 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